核叉头转录蛋白3(Foxp3)在胃间质瘤组织中的表达及其临床病理意义

目的:利用免疫组化技术评估Foxp3在胃间质瘤组织中的表达，并进一步分析Foxp3的表达是否与胃间质瘤患者的临床病理因素和预后相关。方法:收集96例胃间质瘤患者肿瘤及瘤旁组织标本，采用免疫组化方法检测肿瘤及瘤旁组织中Foxp3的表达。进一步分析Foxp3表达水平与患者临床病理因素及预后的关系。结果:与瘤旁正常组织相比，Foxp3在胃间质瘤组织中呈高表达。Foxp3表达与核分裂象、肿瘤大小、肿瘤坏死以及肿瘤危险度分级呈正相关。单因素分析显示Foxp3高表达与总生存率呈负相关，多因素分析显示Foxp3是影响胃间质瘤患者预后的独立危险因素。结论:Foxp3高表达与胃间质瘤患者预后不良有关，Foxp3可能是胃间质瘤潜在的诊断标志物和治疗靶点。

Expression of forkhead box protein 3(Foxp3) in gastric stromal tumors and its clinicopathological significance

Objective:To assess the expression of Foxp3 in gastric GISTs tissues using immunohistochemistry(IHC) techniques and to analyze whether Foxp3 expression is associated with the clinicopathological factors and prognosis of patients with this disease.Methods:Specimens from 96 patients with gastric GISTs were collected and the expression of Foxp3 in tumor and adjacent normal tissues were detected by immunohistochemistry.The association between expression level of Foxp3 with the clinicopathological factors and prognosis of patients were analyzed,respectively.Results:Foxp3 was high-expression in gastric GISTs compared with adjacent normal tissues.Foxp3 expression was positively associated with tumor risk classification,mitotic index,tumor size,tumor necrosis and imatinib administration.Univariate analysis showed that the high expression of Foxp3 was inversely correlated with the overall survival,furthermore,multivariate analysis showed that Foxp3 was an independent prognostic factor for patients with gastric stromal tumor.Conclusion:These results of this study suggested that the high expressions of Foxp3 was associated with a poor prognosis,which may be a potential diagnostic marker and therapeutic target for gastric GISTs.