琥珀酸亚铁联合维生素C纠正宫颈癌伴贫血患者的疗效评价及安全性

目的 探究琥珀酸亚铁联合维生素C纠正宫颈癌患者贫血的临床疗效及安全性问题。方法 筛选放疗科100例宫颈癌伴贫血患者作为研究对象，根据是否规范使用琥珀酸亚铁联合维生素C分为两组，实验组(n=50)采用口服琥珀酸亚铁和维生素C片进行常规治疗，对照组(n=50)未规范行抗贫血治疗。观察并分析两组患者治疗前后的血红蛋白(Hb)水平，规定Hb升高≥20 g/L或至正常值为治疗有效；同时统计两组患者胃肠道不良反应的发生情况。结果 实验组患者贫血治疗的总有效率达48%,其中行术后辅助放化疗的患者总有效率为56%,行根治性放化疗的患者为40%,均明显优于对照组(P<0.05)。并且两组的胃肠道不良反应发生率差异无统计学意义(P>0.05)。结论 琥珀酸亚铁联合维生素C用于治疗宫颈癌患者贫血的疗效显著，安全性可靠，临床上应在此类患者中常规、规范使用。

Efficacy evaluation and safety observation of ferrous succinate combined with vitamin C in patients of cervical cancer with anemia

Objective To investigate the clinical efficacy and safety of ferrous succinate combined with vitamin C in patients of cervical cancer with anemia. Methods A total of 100 patients with cervical cancer and anemia in radiotherapy department were selected. According to whether the standard use of ferrous succinate combined with vitamin C was adopted, they were divided into two groups. The experimental group (n=50) received oral ferrous sulfate and vitamin C tablets for routine treatment, while the control group (n=50) did not receive standard anti-anemia treatment. The hemoglobin (Hb) level of 2 groups before and after treatment was observed and analyzed, and the effective treatment was defined as the increase of Hb value ≥20 g/L or to the normal value. At the same time, the incidence of gastrointestinal adverse reactions in the two groups was analyzed. Results The total effective rate of anemia treatment in the experimental group was 48%, among which the total effective rate of postoperative adjuvant chemoradiotherapy was 56%, and the total effective rate of radical chemoradiotherapy was 40%, which were significantly better than the control group (P<0.05). There was no significant difference in the incidence of gastrointestinal adverse reactions between the two groups (P>0.05). Conclusion Ferrous succinate combined with vitamin C in the treatment of anemia in patients with cervical cancer has significant efficacy and is safe and reliable, so it should be routinely and standardized in clinical practice.