鼻咽癌放化疗患者味嗅觉改变及自我报告症状的相关性

目的 基于鼻咽癌放化疗患者自我报告症状进行分析，探讨症状困扰与味嗅觉改变(taste and smell alterations, TSAs)的相关性，为症状评估和管理策略的制定提供依据。方法 采用横断面调查，于2021年6—12月，采用一般资料调查表、味嗅觉调查表(the Taste and Smell Survey, TSS)、安德森症状量表-头颈部模块(M.D.Anderson Symptom Inventory-Head and Neck, MDASI-HN)对142例鼻咽癌放化疗患者进行问卷调查。结果 TSS总分为10.00(6.00,13.00),味觉维度7.00(5.00,9.00),嗅觉维度3.00(0.00,5.00)。MDASI-HN量表核心症状困扰个数为11.00(7.75,13.00),头颈症状困扰个数为7.00(4.00,9.00),生活干扰个数为5.00(2.00,6.00),其中核心症状困扰、头颈症状困扰与TSAs程度分级呈正相关(P<0.05)。MDASI-HN量表条目睡眠不安、发音/讲话困难、食物或饮水呛咳、工作(包含家务劳动)与TSAs程度分级...

Correlation between changes of taste or smell and self-reported symptoms in patients with nasopharyngeal carcinoma received radiotherapy and chemotherapy

Objective To investigate the correlation between symptom distress and taste and smell changes (TSAs) based on the analysis of self-reported symptoms of nasopharyngeal carcinoma patients received radiotherapy and chemotherapy, so as to provide a basis for symptom assessment and management strategies. Methods A cross-sectional survey was conducted in 142 patients with nasopharyngeal carcinoma received radiotherapy and chemotherapy from June to December 2021, using the general information questionnaire, Taste and Smell Survey (TSS), and the Anderson Symptom Inventory Head and Neck (MDASI-HN). Results The total score of TSS was 10.00 (6.00, 13.00), with the taste dimension of 7.00 (5.00, 9.00) and the smell dimension of 3.00 (0.00, 5.00). The number of MDASI-HN scale core symptoms was 11.00 (7.75, 13.00). The number of head and neck symptoms was 7.00 (4.00, 9.00) and the number of life disturbances was 5.00 (2.00, 6.00). Among them, the number of core symptoms and head and neck symptoms was significantly positively correlated with the TSAs level (P<0.05). The items of the MDASI-HN scale, including restlessness in sleep, dysphonia/speech, choking in food or drinking water, and work (including housework), were not correlated to the TSAs level; while the other items were positively correlated to the TSAs level (P<0.05). Conclusion The symptoms of nasopharyngeal carcinoma patients with radiotherapy and chemotherapy are prominent, and they increases with the degree of taste and smell change. Medical staff should fully consider the correlations between various symptoms and taste and smell, and to improve the corresponding symptoms and taste and smell through treatment, diet and psychological interventions.