Synthesis of new deuterium‐labelled lignanolactones |
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| Authors: | Eija Lepp l ,Monika Pohjoisp ,Jorma Koskimies,Kristiina W h l |
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| Affiliation: | Eija Leppälä,Monika Pohjoispää,Jorma Koskimies,Kristiina Wähälä |
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| Abstract: | Deuteration of several lignanolactones, using 2H3PO4·BF3/2H2O as the deuteration reagent, is described, affording new stable isotopically pure polydeuterated lignans. All aromatic hydrogens are exchanged, including the less active ones. The order of 1H/2H exchange is studied by comparing calculated electrostatic potential values and experimental observations. Labile deuteriums are exchanged back to hydrogens with methanolic HCl to achieve stable isotopically pure compounds. Copyright © 2008 John Wiley & Sons, Ltd. |
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| Keywords: | lignan labelling deuterium phytoestrogen synthesis |
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