康柏西普对增殖型糖尿病视网膜病玻璃体切割术的影响

目的 观察康柏西普眼内注射对增殖型糖尿病视网膜病(PDR)玻璃体切割手术(PPV)的影响. 方法 2014年5月-2016年5月,因PDR行PPV联合硅油注入手术的患者共53例(53眼),按是否进行术前玻璃体腔康柏西普注射,分为单纯PPV组(A组)28例(28眼)及康柏西普玻璃体腔注射联合PPV组(B组)25例(25眼),回顾性分析2组患者的临床资料,并比较2组患者在术中累计出血量、手术时间及术后1周、1月及3月时视网膜出血、视网膜增殖及视力预后的情况. 结果 B组的手术时间、术中累计出血量均少于A组(P<0.05);术后1周时,B组视网膜出血例数少于A组,平均视力高于A组(P<0.05),而视网膜增殖方面2组差别无统计学意义;术后1及3月时,B组较A组视网膜增殖少,视力预后更好(P<0.05),而视网膜出血情况2组差别无统计学意义. 结论 在PDR患者行PPV手术中,术前眼内注射康柏西普可减少术中出血、缩短手术时间、减少术后再出血、减轻视网膜增殖,并能获得更佳的术后视力,为PDR患者保留相对较佳的视功能.

The Effect of Conbercept in the Operation of Proliferative Diabetic Retinopathy

Objective To observe the effect of Conbercept on the surgery of proliferative diabetic retinopathy (PDR).Methods 53 PDR patients (53 eyes) who had undergone pars plana vitrectomy combined silicone oil injection from May 2014 to May 2016 in our hospital were included in this study.Participants were randomly divided into two groups: group A underwent pars plana vitrectomy (PPV) only (n=28), while group B had intravitreal Conbercept injection (IVC) one week before PPV (n=25).The amount of intraoperative hemorrhage, operation duration and postoperative retinal bleeding, retinal proliferation, visual acuity were recorded and analyzed after operation in 1 week, 1 month, and 3 months.Results The average amount of intraoperative hemorrhage, operation duration were lower in group B than that in group A (P<0.05), and the difference was statistically significant.At 1 week after operation, the postoperative retinal bleeding was lower and the visual acuity was higher in group B than that in group A (P<0.05), and the difference was statistically significant.However the difference in retinal proliferation was not statistically significant.At 1 and 3 months after operation, there was less retinal proliferation and higher visual acuity was in group B than that in group A (P<0.05), the difference was statistically significant.However the difference in postoperative retinal bleeding was not statistically significant.Conclusions Conbercept injection before PPV may be beneficial and helpful in reducing intraoperative hemorrhage, operative duration, postoperative retinal bleeding and retinal proliferation, and may improve visual acuity for PDR patients.