| 肠缺血预适应及其心肌保护作用 |
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| 引用本文： | 吕磊,江时森.肠缺血预适应及其心肌保护作用[J].医学研究生学报,2007,20(2):192-195. |
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| 作者姓名： | 吕磊 江时森 |
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| 作者单位： | 南京军区南京总医院心血管内科,江苏南京,210002 |
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| 摘 要： | 肠缺血预适应是肠缺血．再灌注损伤的一种有效预防措施，对心肌也有保护作用。肠缺血预适应的确切机制尚禾完全明了，目前普遍认为是预适应的刺激促使腺苷、缓激肽和去甲肾上腺素等一些内源性活性物质通过不同信号转导途径被释放，从而激活了线粒体ATP敏感的K^＋通道，发挥缺血中的心肌保护作用。
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| 关 键 词： | 肠缺血预适应 心肌保护 缺血-再灌注 |
| 文章编号： | 1008-8199(2007)02-0192-03 |
| 修稿时间： | 2005年1月5日 |
Intestinal ischemic preconditions and its cardioprotection |
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| L Lei,JIANG Shi-sen.Intestinal ischemic preconditions and its cardioprotection[J].Bulletin of Medical Postgraduate,2007,20(2):192-195. |
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| Authors: | L Lei JIANG Shi-sen |
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| Institution: | L(U) Lei,JIANG Shi-sen |
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| Abstract: | Intestinal ischemia preconditioning can protect both the intestine from ischemia-reperfusion injury and myocardium against infarction as well.The mechanism underlying intestinal ischemia preconditioning has not been completely understood yet,but there is now consensus that it involves the release of a number of endogenous substances such as adenosine,bradykinin,and norepinephrine during the preconditioning stimulus,which,most likely via different signal transduction pathways,activate the mitochondrial ATP-sensitive K (KATP) channels. |
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| Keywords: | Intestinal ischemia preconditioning Cardioprotection Ischemia-reperfusion |
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