Clinical value of whole-blood interferon-gamma assay in patients with suspected pulmonary tuberculosis and AFB smear- and polymerase chain reaction-negative bronchial aspirates |
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Authors: | Lee Jaehee Lee Shin Yup Yoo Seung Soo Cha Seung Ick Won Dong Il Park Jae Yong Lee Won-Kil Kim Chang Ho |
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Institution: | Department of Internal Medicine, Kyungpook National University, School of Medicine, Daegu, Republic of Korea. |
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Abstract: | Combining a polymerase chain reaction (PCR) test with bronchoscopy is frequently performed to allow a rapid diagnosis of smear-negative pulmonary tuberculosis (PTB). However, limited data are available concerning clinical judgment in patients with suspected PTB and AFB smear- and PCR-negative bronchial aspirates (BA). The present study evaluated the usefulness of whole-blood QuantiFERON-TB Gold In-Tube (QFT) testing in these patients. Of 166 patients with suspected PTB who had undergone bronchoscopy because of smear-negative sputum or inadequate sputum production, 93 (56%) were diagnosed with culture-positive PTB. Seventy-four patients were either AFB smear- or PCR-positive. In the 75 patients whose BA AFB smear and PCR results were both negative, 19 were finally diagnosed with PTB by culture. The QFT test had a negative predictive value of 91% for PTB. The QFT test may be useful for excluding PTB in patients with suspected PTB whose BA AFB smear and PCR results are both negative. |
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Keywords: | Bronchoscopy QuantiFERON-TB Gold In-Tube Polymerase chain reaction Tuberculosis |
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