| 抗纤软肝冲剂抗大鼠肝纤维化的实验研究 |
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| 引用本文： | 熊益群,严红梅,张赤志.抗纤软肝冲剂抗大鼠肝纤维化的实验研究[J].中国实验方剂学杂志,2000,6(2):28-30. |
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| 作者姓名： | 熊益群 严红梅 张赤志 |
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| 作者单位： | 1. 湖北中医学院肝病研究所,武汉,430061
2. 湖北中医学院96级研究生,武汉,430061 |
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| 基金项目： | 湖北省教委重点资助项目(96A02) |
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| 摘 要： | 采用四氯化碳(CCl4)高脂低蛋白等复合因素诱导的大鼠肝纤维化模型,以秋水仙碱作对照,观察抗纤软肝冲剂对肝功能、免疫学、肝纤维化相关指标、肝组织羟脯氨酸(Hyp)及肝组织病理学的影响.结果抗纤软肝冲剂和秋水仙碱有良好的抗肝纤维化效果,其中抗纤软肝冲剂有显著改善肝功能、调节免疫功能、降低免疫复合物(IC)、降低肝纤维化相关指标和Hyp含量的作用.
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| 关 键 词： | 肝纤维化 中医药疗法 动物实验 抗纤软肝冲剂 |
| 文章编号： | 1005-9903(2000)02-0028-03 |
| 收稿时间： | 9/1/1999 12:00:00 AM |
| 修稿时间： | 1999年9月1日 |
Experimental Studies of the Kangxian Ruangan Granule on Anti-hepatic Fibrosis in Rats |
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| XIONG Yi-qun,YIAN Hong-mei,ZHANG Chi-zhi.Experimental Studies of the Kangxian Ruangan Granule on Anti-hepatic Fibrosis in Rats[J].China Journal of Experimental Traditional Medical Formulae,2000,6(2):28-30. |
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| Authors: | XIONG Yi-qun YIAN Hong-mei ZHANG Chi-zhi |
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| Institution: | XIONG Yi qun 1,YIAN Hong mei 2,ZHANG Chi zhi 1 |
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| Abstract: | The effect and mechanism of the Kangxian Rungan granule (KXRG) on antihepatic fibrosis were studied in rat model of hepatic fibrosis induced by complex factors of CCl\-4 and foods of high fat and low protein.The results showed that KXRG and colchicine had good effects on anti\|hepatic fibrosis.KXRG could obviously improve liver functions,regulate immunologic functions and decrease immunologic compound(IC),relevant index on hepatic fibrosis and the level of hydroxyproline(Hyp). |
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| Keywords: | experimental hepatic firbrosis therapeutic method of traditional Chinese medicine experiment on animals |
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