Evaluation of familial influences on
the course and severity of schizophrenia among US and Indian
cases |
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Authors: | Smita?N?Deshpande Triptish?Bhatia Joel?Wood Jaspreet?S?Brar B?K?Thelma Rohan?Ganguli Richard?Day Irving?I?Gottesman Email author" target="_blank">Vishwajit?L?NimgaonkarEmail author |
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Institution: | (1) Dr Ram Manohar Lohia Hospital, New Delhi, India;(2) Indo US Project on Schizophrenia Genetics, Dr Ram Manohar Lohia Hospital, New Delhi, India;(3) Dept. of Psychiatry, WPIC Room 443, University of Pittsburgh, School of Medicine, 3811 OHara Street, Pittsburgh, PA 15213, USA;(4) Dept. of Genetics, Delhi University, New Delhi, India;(5) Graduate School of Public Health, University of Pittsburgh, Pittsburgh, USA;(6) Depts. of Psychiatry and Psychology, University of Minnesota, Minneapolis, USA |
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Abstract: | Abstract.Background: Prior studies suggest familial (possibly genetic)
influences on the course of schizophrenia.Aims: The aim of this study was to compare familial influences
on the course and severity of schizophrenia in two independent
samples.Method: Thirteen selected measures were compared among affected
sibling pairs (ASPs) from Pittsburgh, USA and New Delhi, India
(48 US pairs, 53 Indian pairs). For each ASP proband, an
unrelated patient was selected randomly from a suitable pool of
cases ascertained in the same study (Sibpair proband—comparison
case or S-C pairs). Correlations between these pairs were
compared.Results: The correlations varied by item and by site. Significant
correlations for longitudinal course and pattern of severity
were noted among the ASPs from USA, but did not remain
significant following corrections for multiple comparisons.
Comparisons between the correlations for ASPs and the S-C pairs,
used to estimate familial effects, yielded trends for the ASP
correlations to be numerically larger than the S-C correlations
in both samples. Separate cross-site comparisons revealed
several significant differences with regard to several
demographic and clinical variables. The possible impact of the
cross-site variations on the observed ASP correlations is
discussed.Conclusions: Though familial factors did not appear to have a
significant impact on course/severity using this novel design,
the suggestive trends need to be examined in larger
samples. |
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Keywords: | schizophrenia course severity India developing country familial |
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