乳腺及甲状腺肿块术中冰冻切片误诊分析

目的探讨乳腺及甲状腺肿块冰冻切片诊断的临床意义和误诊原因分析。方法分析我院1995年12月～2004年6月术中590例乳腺肿块及776例甲状腺肿块冰冻切片与石蜡切片诊断结果。结果590例乳腺肿块冰冻切片报告中，确诊586例，确诊率为99．32％；误诊4例，均为假阴性，误诊率为0．68％。776例甲状腺冰冻报告中，确诊758例，确诊率97．68％；误诊15例，误诊率1．93％，其中假阴性14例，癌漏诊率达10．69％。结论冰冻切片对乳腺及甲状腺病变有定性诊断意义，但是冰冻取材的局限、病变形态的多样性、隐匿性以及冰冻切片的质量，是造成误诊和延期诊断的主要原因。

Misdiagnosis analysis of intraoperative frozen section in breast neoplasms and thyroid neoplasms

Objective To analyse the clinical significance of frozen section for the diagnosis of breast neoplasms and thyroid neoplasms and to discuss the cause of wrong diagnosis.Methods The diagnostic reports of intraoperative frozen sections and paraffin sections were analyzed retrospectively in 590 cases of breast neoplasms and 776 cases of thyroid neoplasms.Results Five hundred and eighty-six cases(99.32%) were diagnosed correctly and 4 were misdiagnosed with intraoperative frozen sections.The original diagnosis of frozen section was accurate in 758 of 776 cases(97.7%),wrong diagnosis in 15 of 776(1.9%).False of negative in thyroid carcinoma was 14 of 131(10.7%).Conclusion Frozen section is valuable in the diagnosis of breast neoplasms and thyroid neoplasms.The factors affecting the accuracy of frozen section diagnosis include the quality of the section,the diversity of the disease and the limition of the section material.