苏州市结核病耐多药情况分析

目的 了解苏州市地区感染结核分枝杆菌(Mycobacterium tuberculosis,MTB)的结核病患者耐多药情况.方法 对2008年9月～2011年5月期间在苏州大学附属传染病医院就诊的肺结核病患者的临床分离株进行菌型鉴定后,用药敏罗氏培养基进行药物敏感性试验,分析结核病患者的耐多药情况.结果 苏州市地区近三年期结核病耐多药发生率总体为10.5％,2010年及2011年度耐多药发生率(18.2％)显著高于2008及2009年度(x2 =19.9,P＜0.01),且复治组耐多药发生率显著高于初治组(x2 =70.5,P＜0.01).结论 苏州大学传染病医院收治的结核病耐多药率呈上升趋势,且复治组高于初治组.

Analysis of multi-drug resistance of Mycobacterium tuberculosis derived from tuberculosis patients in Suzhou city

Objective To investigate the multi-drug resistance of of Mycobacterium tuberculosis derived from tuberculosis patients diagnosed at the affiliated infectious hospital of soochow university in Suzhou.Methods From September 2008 to May 2011,the type of clinical isolates from the hospital were demonstrated and then the multi-drug resistance of Mycobacterium tuberculosis from the patients was analyzed by drug sensitive test.Results The multi-drug resistance rate of 1749 Mycobacterium tuberculosis was 10.5%.The multi-drug resistance rate arising during 2010 and 2011 was 18.2%,which was profoundly higher than that occurred in 2008 and 2009.Conclusion The multi-dug resistance rate of Mycobacterium tuberculosis from the tuberculosis patients in Suzhou city is high and presents increasing.