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| 白藜芦醇自微乳软胶囊的制备及粒度测定 | |
| 引用本文： | 蒋燕,陆继好,陈建伟. 白藜芦醇自微乳软胶囊的制备及粒度测定[J]. 中医药导报, 2012, 18(8): 80-82 |
| 作者姓名： | 蒋燕 陆继好 陈建伟 |
| 作者单位： | 1. 南京中医药大学,江苏,南京,210046;无锡卫生高等职业技术学校,江苏,无锡,214028 2. 江苏信孚药业有限公司,江苏,无锡,214028 3. 南京中医药大学,江苏,南京,210046 |
| 基金项目： | 江苏省高校自然科学基金，江苏高校优势学科建设工程资助项目 |
| 摘 要： | 目的:制备白藜芦醇自微乳软胶囊,建立粒径测定方法,控制产品质量。方法:通过测定白藜芦醇溶解度,以及成乳后的粒径、自乳化时间和色泽为指标,对油相、乳化剂、助乳化剂进行筛选,制备白藜芦醇自微乳软胶囊;通过稳定性、精密度试验建立自微乳化后乳滴直径测定方法。结果:油相、乳化剂、助乳化剂比例为1∶2∶2时可获得较好的自乳化效果,平均自微乳粒径为25 nm。结论:该方法准确,简便,重现性好,专属性强,可用于该产品的质量控制。 |
| 关 键 词： | 白藜芦醇 软胶囊 自微乳化 粒度 |
Preparation and Diameter Determination of soft capsules resveratrol |
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| Jiang Yan , Lu Jihao , Chen Jianwei. Preparation and Diameter Determination of soft capsules resveratrol[J]. GUIDING JOURNAL OF TCM, 2012, 18(8): 80-82 | |
| Authors: | Jiang Yan Lu Jihao Chen Jianwei |
| Affiliation: | 1(corresponding author)(1.Nanjing University of Chinese Medicine Nanjing 210046,China;2.Wuxi Higher Health Vocational Technology School,Wuxi 214028,China;3.Jiangsu Safepharmaceutical Co.,LTD Wuxi 214028,China) |
| Abstract: | Objective: To prepare soft capsules resveratrol,particle size measurement methods and control quality of product.Methods The determination of resveratrol solubility,the particle size after into the milk,self-emulsifying time and color as an index,oil phase,emulsifier and filter emulsifier were screened to prepare soft capsules resveratrol;,create a custom micro precision of drop diameter was established by stability and precision test.Results: The ratio(1∶2∶2) of oil phase,emulsifie and filter emulsifier can get better self-emulsifying effect;the average particle size from the micro emulsion 25 nm.Conclusion: This method is simple,accurate,reproducible and specific;and it is can be applied for the quality control of this medication. |
| Keywords: | Resveratrol Soft Capsule Micro-emulsion Granularity |
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