丹紫康膝冲剂对兔膝骨性关节炎软骨水及血清碱性磷酸酶的影响

目的:探讨丹紫康膝冲剂治疗膝关节骨性关节炎的疗效。方法:将兔随机分成6组,除正常组外,丹紫康膝冲剂高剂量组、中剂量组、低剂量组(简称丹紫高、中、低剂量组)、壮骨关节丸组(简称壮骨组)、模型组5组兔行左膝关节1周内分别于第1,4,7天注射0.5 mL 4%木瓜蛋白酶造模及药物干预后,观察关节软骨并检测关节软骨含水率和血清碱性磷酸酶含量。结果:模型组与正常组软骨含水率比较,差异有统计学意义(P<0.01),丹紫高、中、低剂量组、壮骨组与模型组软骨含水率比较,差异有统计学意义(P<0.01);模型组与正常组血清碱性磷酸酶含量比较,差异有统计学意义(P<0.01),丹紫高、中、低剂量组、壮骨组与模型组血清碱性磷酸酶含量比较,差异有统计学意义(P<0.01)。结论:丹紫康膝冲剂能改善兔膝关节骨性关节炎软骨中含水率和血清碱性磷酸酶含量,高、中剂量组优于低剂量组。

Study on the impact of Dan zi kang xi granules on the moisture of cartilage and alkaline phosphatase of serum of knee osteoarthritis of rabbits

Objective:To explore the efficacy of Danzikangxi granules in the treatment of the knee osteoarthritis.Method:Rabbits were randomly divided into 6 groups,Other than the normal group,Danzikangxi granules high dose group、medium dose group、low dose group(Short for Danzi high、medium、low dose group)、model control group and Zhuangguguanjiewan group(Short for Zhuanggu group) were,respectively,in 1、4、7 days a week injection of 0.5 mL 4% papain.And then rabbits were treated with drug or water.Observing the general condition of articular cartilage and detecting water ratio of articular cartilage and alkaline phosphatase of serum.Results: The difference in rate of moisture between model group and normal group was statistically significant(P<0.01).The differences in rate of moisture between Danzi high、medium、low dose group、Zhuanggu group and model group were statistically significant(P<0.01).The differences in the content of alkaline phosphatase between model group and normal group was statistically significant(P<0.01).The differences in the content of alkaline phosphatase between Danzi high、medium、low dose group 、Zhuanggu group and model group were statistically significant(P<0.01).Conclusion:Danzikangxi granules can adjust the content of moisture and alkaline phosphatase of serum of the knee osteoarthritis of rabbits,and high、medium dose better than low dose.