奥沙利铂联合卡培他滨治疗晚期大肠癌的临床观察

目的：观察奥沙利铂联合卡培他滨治疗晚期大肠癌的疗效和毒副反应。方法：38例均为术后有残留病灶或复发转移有可测量病灶的晚期大肠癌患者，静脉滴注奥沙利铂130mg／m^2，d1；卡培他滨2500mg／m^2，分早晚2次口服，d1～d14每3周为Ⅰ周期。结果：38例患者中，CR2例，PR16例，SD10例，PD10例，近期有效率（CR＋PR）为47．3％，中位生存期（MST）13个月，中位疾病进展时间（TTP）7．9个月。毒副反应主要为手足综合征、神经毒性，多为Ⅰ～Ⅱ度。结论：奥沙利铂联合卡培他滨的方案疗效高，毒副反应小，患者易耐受，生活质量提高。

Combination of oxaliplatin and capecitabine in the treatment of advanced colorectal carcinoma

Objective:To observe the clinical efficacy and toxicity of oxaliplatin plus capecitabine for the treatment of advanced colorectal carcinoma.Methods:Thirty-eight patients having residual focuses or recurrence or metastases which could be measured.Oxaliplatin was given at a dose of 130mg/m2 by intravenous injection at day 1;Capecitabine was orally given at a dose of 2 500mg/m2,twice a day for two weeks.Every 3 weeks was a cycle.Results:Among 38 patients,the response rate(CR+PR)was 47.3% with 2 CR,16 PR,10 SD,10 PD.MST was 13 months,mTTP was 7.9 months.The major side effects were hand-foot syndrome in 14(36.8%),neural toxity 19(50%),diarrhea 14(35.8%).Conclusion:Oxaplatin combined with capecitabine is well tolerated and is effective for the patients with advanced colorectal carcinoma.