| 胰十二指肠切除术对胰头癌患者CD4~+CD25~+调节性T细胞的影响及临床意义 |
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| 引用本文： | 林琳,梁健,马作红,郭大伟,王学范,付庆才,孙文郁,姜洪磊,金俊哲,姜晓峰.胰十二指肠切除术对胰头癌患者CD4~+CD25~+调节性T细胞的影响及临床意义[J].中国普外基础与临床杂志,2011,18(1):51-54. |
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| 作者姓名： | 林琳 梁健 马作红 郭大伟 王学范 付庆才 孙文郁 姜洪磊 金俊哲 姜晓峰 |
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| 作者单位： | 1. 中国医科大学附属第四医院肝胆胰外科,辽宁沈阳,110032
2. 辽宁省肿瘤医院肝胆胰外科,辽宁沈阳,110043 |
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| 基金项目： | 辽宁省教育厅高等学校科研计划项目(项目编号:2008824)~~ |
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| 摘 要： | 目的研究胰头癌患者外周血中CD4+CD25+调节性T细胞(Treg)比例及其在手术前、后的变化趋势。方法采用流式细胞仪检测胰头癌患者及正常对照组外周血中CD4+CD25+调节性T细胞的数量,同时监测CD4+/CD8+比值,并进行手术前、后的比较。结果胰头癌患者术前外周血中CD4+CD25+和CD4+CD25highTreg所占比例较正常对照组高(P<0.05),术后则出现不同程度下降,以术后第3天下降最明显(P<0.01,P<0.05);胰头癌患者术后CA19-9水平低于术前,以术后第14天下降明显(P<0.05)。CD4+CD25highTreg与CA19-9的变化趋势大致相同。胰头癌患者术前CD4+/CD8+比值比正常对照组低(P<0.05),手术后进一步降低,于手术后第7天达最低(P<0.05)。结论胰十二指肠切除术可能有助于机体抗肿瘤免疫的恢复,胰头癌患者围手术期可作为免疫干预的重要窗口期,CD4+CD25+调节性T细胞可作为免疫干预的靶点。
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| 关 键 词： | 胰头癌 胰十二指肠切除术 调节性T细胞 免疫耐受 |
Influence of Pancreatoduodenectomy on CD4+CD25+ T Cells in Patients with Pancreatic Head Carcinoma and Its Clinical Significance |
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| LIN Lin,IANG Jian,MA Zuo-hong,GUO Da-wei,WANG Xue-fan,Fu Qing-cai,SUN Wen-yu,JIANG Hong-lei,JIN Jun-zhe,JIANG Xiao-feng.Influence of Pancreatoduodenectomy on CD4+CD25+ T Cells in Patients with Pancreatic Head Carcinoma and Its Clinical Significance[J].Chinese Journal of Bases and Clinics In General Surgery,2011,18(1):51-54. |
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| Authors: | LIN Lin IANG Jian MA Zuo-hong GUO Da-wei WANG Xue-fan Fu Qing-cai SUN Wen-yu JIANG Hong-lei JIN Jun-zhe JIANG Xiao-feng |
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| Institution: | LIN Lin1,LIANG Jian1,MA Zuo-hong2,GUO Da-wei1,WANG Xue-fan1,FU Qing-cai2,SUN Wen-yu1,JIANG Hong-lei1,JIN Jun-zhe1,JIANG Xiao-feng1.1.Department of Hepatiobiliaripancreatic Surgery,The Fourth Affiliated Hospital of China Medical University,Shenyang 110032,Liaoning Province,China,2.Department of Hepatiobiliaripancreatic Surgery,Cancer Hospital of Liaoning Province,Shenyang 110043 |
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| Abstract: | Objective To investigate the proportion of peripheral blood CD4+CD25+ regulatory T cells(Tregs) in patients with pancreatic head carcinoma,the dynamic changes of these cells before and after pancreatoduodenectomy were also analyzed.Methods The proportions of peripheral blood CD4+CD25+ Tregs in patients with pancreatic head carcinoma and normal individuals were examined by using flow cytometric analysis.The CD4+/CD8+ ratio was also studied before and after operation.Results The patients with pancreatic head ... |
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| Keywords: | Carcinoma of pancreatic head Pancreatoduodenectomy Regulatory T cells Immunotolerance |
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