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桡动脉增强指数与心血管病危险及动脉僵硬度相关分析
作者姓名:Xiao WK  Ye P  Luo LM  Liu DJ  Wu HM
作者单位:1. 解放军总医院南楼心血管二科, 北京,100853
2. 解放军总参谋部警卫局卫生保健处
摘    要:目的 探讨桡动脉增强指数(rAI)与心血管病危险及动脉僵硬度相关性。方法 北京地区4985例(男2417例,女2568例),年龄18 ~96(50.9±14.7)岁,测量左侧rAI;应用脉搏波传播速度(PWV)自动测量系统测定颈-股动脉PWV(CFPWV)和颈-桡动脉PWV(CRPWV)。并对其中没有心血管病的人群应用Framingham危险评分和中国缺血性心血管病危险评分分别计算个体心血管病风险。结果 女性的rAI显著高于男性(83.18±12.36)%比(71.93±15.22)%,P<0.01]。相关分析rAI无论与两种心血管评分还是与CFPWV、CRPWV均有显著相关性;当校正了年龄、舒张压、吸烟、心率、身高、腰围及空腹血糖后rAI仍与Framingham评分及中国心血管评分有相关性,其中男、女性相关系数r分别为0.17、0.09和0.12、0.08(P值均<0.05),rAI仅与CFPWV有相关性(男女分别为r=0.14、0.10,P<0.01),而与CRPWV无相关性。在相对年老的人群中(>50岁)rAI与心血管病危险评分及PWV的相关性减弱。结论 rAI可能是一种预测心血管病风险及评估动脉僵硬度的有价值工具;作为危险分层的工具,rAI可能更适用于相对年轻的人群。

关 键 词:动脉硬化  桡动脉增强指数

Radial augmentation index is associated with cardiovascular risk and arterial stiffness
Xiao WK,Ye P,Luo LM,Liu DJ,Wu HM.Radial augmentation index is associated with cardiovascular risk and arterial stiffness[J].Chinese Journal of Internal Medicine,2011,50(10):831-835.
Authors:Xiao Wen-kai  Ye Ping  Luo Lei-ming  Liu De-jun  Wu Hong-mei
Institution:Second Department of Cardiology, PLA General Hospital, Beijing, China. xiaowk301@sina.com
Abstract:Objective To investigate whether radial augmentation index (AI) associates with cardiovascular risk as well as arterial stiffness.Methods A total of 4985 subjects, 2417 men and 2568 women, aged 18-96 (50.9 ± 14.7)years,were recruited.AI was measured in the left radial artery using tonometry Colin HEM-9000AI.Carotid-femoral PWV (CFPWV) and carotid-radial PWV (CRPWV) were examined by automatic pulse wave velocity (PWV) measuring system.Framingham risk score and Chinese ischemic cardiovascular disease risk score were applied upon subjects without cardiovascular disease to calculate individual cardiovascular risk respectively.Results Radial AI (rAI) was significantly higher in women than in men(83.18 ± 12.36)% vs (71.93 ± 15.22)%, P <0.01].Simple correlation analysis showed rAI was significantly correlated to two cardiovascular risk scores or CFPWV and CRPWV.After adjusted for multi-factors, rAI was still significantly correlated to Framing, ham risk score or Chinese ischemic cardiovascular disease risk score (r = 0.17 and 0.12) in men respectively (P < 0.05), while r were 0.09 and 0.08 in women respectively (P < 0.05).In multivariate analysis, there was a significant association between CFPWV and rAI (r = 0.14 in men, r = 0.10 in women, P < 0.01), whereas the relation ship between CRPWV and rAI was not found.The relationship between rAI and cardiovascular risk or PWV became weaker for those aged above 50 years.Conclusion Augmentation index might be a useful marker of cardiovascular risk and arterial stiffness, which could be more feasible for younger subjects as a tool for risk differentiation.
Keywords:Arteriosclerosis  Radial artery augmentation index
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