垂体前叶功能减退症117例临床分析

目的 探讨垂体前叶功能减退症临床变化特征.方法 回顾性分析本院1994年至2010年住院及部分门诊117例患者的资料.结果 男性占60.68％,女性39.32％；诊断时年龄13 ～79岁,40岁以上占79.12％；鞍区肿瘤57例(40.17％),发生在手术和(或)放疗后55例(占鞍区肿瘤的96.49％),经额入路手术患者35例(66.04％),经蝶入路手术患者18例(33.96％)；首发症状以ACTH缺乏致乏力、厌食、恶心呕吐的低钠血症108例(92.31％)最常见；伴中枢性尿崩症23例(19.66％),伴冠心病82例(70.09％).结论 本症由于致病因素的变化,发病人群、首发症状及受累激素均已发生很大变化.患者男性多于女性,发病年龄偏高,病因以垂体瘤为主.

Anterior pituitary hypofunction: a clinical analysis of 117 cases

Objective To investigate the clinical features of anterior pituitary hypofunction.Methods A retrospective analysis was carried out on the data of 117 patients with anterior pituitary hypofunction during 1994-2010.Results There were 60.68％ male and 39.32％ female patients respectively.The onset age was from 13 to 79 years,with 79.12％ of the patients more than 40 years old.There were 57 cases with sellar tumors ( 40.17％ ),in which 55 cases( 96.49％ )were operated and (or) treated with radiotherapy.35 cases were operated via the frontal approaches( 66.04％ ) and 18 cases underwent transsphenoidal surgery ( 33.96％ ).There were 108 cases with hyponatremia with the first symptoms of weakness,anorexia,nausea,and vomiting induced by ACTH deficiency (92.31％ ).There were 23 cases accompanied with central diabetes insipidus( 19.66％ )and 82 cases with coronary heart disease( 70.09％ ).Conclusion Owing to the difference in etiological factors,the incidence,early symptoms,and the hormones involved are greatly different.The main cause is pituitary tumor,which occured more in aged person,more in males than females.