原发性醛固酮增多症患者中代谢综合征的患病情况

目的 评价原发性醛固酮增多症（原醛症）患者中代谢综合征(MS)的患病率及其与醛固酮水平的关系。方法 收集2008年10月至2010年7月本院诊治的216例原醛症患者的临床资料并进行回顾性统计，分析该人群中MS的患病情况。结果 (1)原醛症患者的MS患病率为47.69％；在MS各组分中，超重或肥胖、高甘油三酯(TG)血症、糖调节受损、低高密度脂蛋白胆固醇( HDL-C)血症及糖尿病的检出率依次为51.13％、22.52％、19.62％、3.82％和2.94％，中重度高血压为91.87％。(2)在MS各组分中（除高血压外），位于前3位的组合依次为超重或肥胖+高TG血症、超重或肥胖+低HDL-C血症以及超重或肥胖+糖尿病，检出率分别为35.19％、15.74％和11.57％。(3)随着血醛固酮水平的升高，超重或肥胖及糖调节受损检出率逐渐增高；高TG血症、低HDL-C血症以及MS检出率在醛固酮最高水平组高于低水平组。(4)原醛症患者中MS患病率维吾尔族(64.0％)高于汉族(45.3％)，哈萨克族(42.9％)则低于汉族，差异有统计学意义(P＜0.05)。结论原醛症患者MS患病率高，MS及其组分患病率随醛固酮水平增加而增高。

Prevalence of metabolic syndrome in patients with primary aldosteronism

Objective To explore the prevalence of metabolic syndrome (MS) in patients with primary aldosteronism(PA) and the correlation with plasma aldosterone concentration. Methods The incidence of MS was retrospectively analyzed in 216 patients with PA from October 2008 to July 2010. Results( 1 ) The prevalence of MS was 47. 69％ in the patients with PA. As the individual components of MS, the incidence of overweight/obesity,raised blood triglyceride ( TG ) level, impaired glucose regulation ( IGR), lowered high-density lipoprotein-cholesterol ( HDL-C), and diabetes mellitus( DM ) was 51.13％, 22. 52％, 19.62％, 3.82％, and 2.94％, respectively. (2)The most common combination of MS components was overweight/obesity+high TG, followed by overweight/obesity+ lowered HDL-C, and overweight/obesity + DM, with the incidence of 35. 19％, 15.74％, and 11.57％,respectively. (3) The incidence of overweight/obesity and IGR was raised progressively with the increasing plasma aldosterone level. (4) The prevalence of MS was significantly lower in Han patients (45.3％) than in Uygur ( 64. 0％ ), but higher than in Kazakh (42. 9％, both P＜0. 05 ). Conclusions The prevalence of MS in patients with PA was high. The prevalences of MS and its components were gradually rising with plasma aldosterone level.