分化型甲状腺癌预后相关因素分析并文献复习

对分化型甲状腺癌(DTC)预后相关因素进行分析并复习文献,为提高DTC诊断治疗水平及生存率提供依据.回顾性随访分析经术后组织病理学证实为DTC的150例(女性113例,男性37例)病例资料,乳头状癌131例(87.3％),滤泡癌19例(12.7％).随访4.15 ～31年,存活140例(93.3％),复发30例(20.0％),死亡10例(6.7％).手术方式中近全或次全切手术83例(55.3％),局部切除64例(42.7％),全切3例(2.0％).63例行淋巴结切除者中45例(71.4％)检出淋巴结转移.发病年龄、就诊时肿瘤大小及早期转移率在死亡组与存活组、复发组与未复发组间有统计学差异(P＜0.05).年龄、就诊时肿瘤大小及早期转移影响DTC预后.

Prognostic factors of differentiated thyroid carcinomas and review of literatures

Prognostic factors of differentiated thyroid carcinomas ( DTC ) were analyzed and the related literatures were systematically reviewed in order to justify the diagnostic and therapeutic modalities for improving the patient′s survival.150 patients ( female,n =113 ; male,n =37 ) with histopathologically diagnosed DTC,including papillary thyroid carcinoma ( n =131,87.3％ ) and follicular thyroid carcinoma ( n =19,12.7％ ),were postoperatively followed up and their clinical data were retrospectively reviewed.Patients were followed up for 4.15-31 years wherein 140 patients( 93.3％ ) survived but with relapse in 30 patients( 20.0％ ),and 10 patients( 6.7％ ) died.Surgical procedures consisted of near-total or subtotal thyroidectomy ( n =83,55.3％ ),partial thyroidectomy ( n =64,42.7％ ),and total thyroidectomy ( n =3,2.0％ ).Out of the patients receiving lymph node dissection ( n =63 ),45 patients( 71.4％ ) had detectable lymph node metastasis.Age of onset,tumor size at initial visit,and early metastasis showed the statistically significant difference between mortality group and survival group (P＜ 0.05 ),as well as between relapse group and relapse-free group( P＜0.05 ).Age of onset,tumor size at initial visit,and early metastasis are prognostic factors for DTC.