| 吡格列酮对肥胖小鼠原代棕色脂肪细胞分化和功能基因表达的影响 |
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| 引用本文： | 胡淼,刘娟,王龙,丁国宪.吡格列酮对肥胖小鼠原代棕色脂肪细胞分化和功能基因表达的影响[J].中华内分泌代谢杂志,2011,27(11). |
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| 作者姓名： | 胡淼 刘娟 王龙 丁国宪 |
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| 作者单位： | 1. 210029 南京,南京医科大学笫一附属医院老年内分泌科;南京医科大学附属常州笫二人民医院老年医学科
2. 南京医科大学笫一附属医院老年内分泌科, 南京,210029 |
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| 基金项目： | 国家自然科学基金资助项目 |
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| 摘 要： | 观察吡格列酮对肥胖小鼠原代棕色脂肪(brown adipose tissue,BAT)细胞分化和功能基因表达的影响,并为治疗肥胖相关疾病寻找新思路.结果显示吡格列酮通过增强特异基因表达、促进分化成脂、提高线粒体功能等方面增强BAT细胞功能(P＜0.05)；这可能是吡格列酮改善机体代谢的重要原因.
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| 关 键 词： | 吡格列酮 棕色脂肪 PPARγ 解耦联蛋白 |
Effects of pioglitazone on the expression of genes relative to differentiation and function of primary brown adipose tissue cells in mice with diet-induced obesity |
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| HU Miao,LIU Juan,WANG Long,DING Guo-xian.Effects of pioglitazone on the expression of genes relative to differentiation and function of primary brown adipose tissue cells in mice with diet-induced obesity[J].Chinese Journal of Endocrinology and Metabolism,2011,27(11). |
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| Authors: | HU Miao LIU Juan WANG Long DING Guo-xian |
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| Abstract: | The effect of pioglitazone on the expression of genes relative to differentiation and function of primary brown adipose tissue cells was detected for the new treatment of obesity and type 2 diabetes.The results showed that pioglitazone promoted the differentiation and function of brown adipocytes( P＜0.05 ). |
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| Keywords: | Pioglitazone Brown adipose tissue PPA Rγ′ Uncoupling protein-1 |
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