| MMP-2、CD147蛋白在大肠癌中的表达及其临床意义 |
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| 引用本文： | 李俐,赵建华,王劲松,樊克武.MMP-2、CD147蛋白在大肠癌中的表达及其临床意义[J].江苏医药,2006,32(2):120-121. |
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| 作者姓名： | 李俐 赵建华 王劲松 樊克武 |
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| 作者单位： | 210006,南京医科大学附属南京第一医院病理科;210006,南京医科大学附属南京第一医院病理科;210006,南京医科大学附属南京第一医院病理科;210006,南京医科大学附属南京第一医院病理科 |
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| 摘 要： | 目的 探讨MMP-2、CD147蛋白在大肠癌中的表达及其意义。方法 采用SP免疫组织化学法检测45例大肠癌石蜡标本中MMP-2、CD147蛋白的表达及其临床意义。结果45例大肠癌中MMP-2的阳性率为42．22％（19／45），CD147的阳性率为53．33％（24／45），两者的阳性表达均与大肠癌的浸润深度、Dukes分期和淋巴结转移有关；大肠癌中MMP-2和CD147的表达具有相关性。结论 MMP-2和CD147蛋白的高表达与大肠癌浸润转移、病理分期有关，两者联合检测可作为评估大肠癌预后的生物学指标之一。
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| 关 键 词： | 大肠癌 MMP-2 CD147 |
| 收稿时间： | 2004-12-02 |
| 修稿时间： | 2004年12月2日 |
Expression and significance of MMP-2 and CD147 protein in colorectal carcinoma |
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| LI Li, ZHAO Jianhua, WANG Jinsong,et al..Expression and significance of MMP-2 and CD147 protein in colorectal carcinoma[J].Jiangsu Medical Journal,2006,32(2):120-121. |
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| Authors: | LI Li ZHAO Jianhua WANG Jinsong |
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| Institution: | Department of Pathology, Affiliated Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, CHINA |
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| Abstract: | Objective To investigate the expression and significance of MMP-2 and CD147 protein in colorectal carcinoma. Methods Immunohistochemical technique was used to detect MMP-2 and CD147 protein expression in 45 patients with colorectal carcinoma. Results The positive rates of MMP-2 and CD147 protein in colorectal carcinoma were 42.22% and 53.33% respectively. A strong correlation was found between MMP-2 and CD147 protein expression and tumor infiltration, Dukes stage and lymphonode metastasis. MMP-2 expression was correlated with CD147. Conclusion The high expression of MMP-2 and CD147 protein is related to the invasion and metastasis of colorectal carcinoma. Their positive expression may be used as one of the markers for predicting the prognosis of patients. |
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| Keywords: | MMP-2 CD147 |
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