98例原发性胃淋巴瘤的临床诊治分析

目的探讨原发性胃淋巴瘤（PGL）的临床特点及诊治方法。方法回顾性分析中国医学科学院肿瘤医院1994年1月至2006年12月所收治的98例PGL患者的临床资料，总结其临床特点和治疗方式对患者生存期的影响。结果腹痛为本组病例最常见的临床症状，占51．0％。患者全部为Ⅰ、Ⅱ期肿瘤；PGL术前的确诊率为56．5％，1、3、5年总生存率分别为95．1％、86．0％和73．0％；Ⅰ期患者的5年生存率为89．5％，Ⅱ期患者为66．7％，两者差异有统计学意义（P=0．029）。手术治疗组患者5年生存率77．2％，非手术治疗组患者为75．0％，两者差异无统计学意义（P=0．794）。结论对于PGL，可首选全身化疗为主的治疗模式；在出现严重的消化道并发症、无明确活检病理诊断或化疗无效时可考虑手术治疗。

Clinical analysis of 98 cases of primary gastric lymphoma

OBJECTIVE: To explore the clinical characteristics, diagnosis and treatment regimens for the primary gastric lymphoma (PGL). METHODS: The data of 98 PGL patients treated from January 1994 to December 2006 were collected and analyzed retrospectively. RESULTS: Abdominal pain was the common symptom of PGL. All the patients were at stage I or stage II, and the preoperative diagnosis rate was 56.5%. The overall 1-, 3- and 5-year survival rates were 95.1%, 86.0% and 73.0% respectively. The 5-year survival rates of stage I and stage II patients were 89.5% and 66.7% respectively, and the difference was significant. The 5-year survival rate of patients received operations was 77.2% and that without operation was 75.0%, the difference was not significant. CONCLUSIONS: The therapy based on chemotherapy is preferred for the treatment of PGL. In the cases of serious gastrointestinal complications, indefinite pathological diagnosis or non-effective chemotherapy, operations should be considered.