| 黄芪多糖对HSC-T6细胞增殖及胶原产生的影响 |
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| 引用本文： | 张霄翔,杨雁,陈敏珠. 黄芪多糖对HSC-T6细胞增殖及胶原产生的影响[J]. 中国临床药理学与治疗学, 2003, 8(6): 645-647 |
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| 作者姓名： | 张霄翔 杨雁 陈敏珠 |
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| 作者单位： | 1. 安徽中医学院药剂教研室,合肥,230038,安徽
2. 安徽医科大学临床药理研究所,合肥,230032,安徽 |
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| 摘 要： | 目的研究黄芪多糖(APS)对体外HSC-T6细胞增殖和胶原合成的影响.方法采用血清刺激大鼠肝星状细胞(HSC-T6),用[3H]-TdR和[3H]-Proline掺入法分别检测其增殖和胶原合成的活性.结果低浓度APS可明显降低由血清刺激的HSC-T6细胞的增殖和胶原合成的活性.高浓度APS(≥80 mg*L-1) 可明显促进HSC-T6细胞增殖.结论低浓度APS对HSC-T6细胞的增殖和胶原合成的活性有抑制作用,且APS对HSC-T6细胞增殖有双向调节作用.
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| 关 键 词： | 药理学 黄芪多糖 HSC—T6细胞系 增殖 胶原 肝纤维化 |
| 文章编号： | 1009-2501(2003)06-0645-03 |
| 修稿时间： | 2003-04-04 |
Effect of total polysaccharide of Astragalus on proliferation and collagen production of HSC-T6 cells |
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| ZHANG Xiao-Xiang ,YANG Yan,CHEN Min-Zhu Institute of Clinical Pharmacology,Anhui Medical University,Hefei ,Anhu i,China. Effect of total polysaccharide of Astragalus on proliferation and collagen production of HSC-T6 cells[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2003, 8(6): 645-647 |
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| Authors: | ZHANG Xiao-Xiang YANG Yan CHEN Min-Zhu Institute of Clinical Pharmacology Anhui Medical University Hefei Anhu i China |
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| Affiliation: | ZHANG Xiao-Xiang 1,YANG Yan,CHEN Min-Zhu Institute of Clinical Pharmacology,Anhui Medical University,Hefei 230032,Anhu i,China, 1 Department of Pharmacy,Anhui College of Traditional Chinese Medi cine,Hefei 230038,Anhui,China |
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| Abstract: | |
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| Keywords: | pharmacology total polysaccharide of Astragalus HSC-T6cell proliferation collagen hepatic fibrosis |
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