| Study on 4977-bp deletion mutation of mitochondrial DNA in lung cancer |
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| 引用本文： | 戴纪刚 肖颖彬 闵家新 张国强 姚珂 周人杰. Study on 4977-bp deletion mutation of mitochondrial DNA in lung cancer[J]. 中国人民解放军军医大学学报, 2005, 20(6): 345-350 |
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| 作者姓名： | 戴纪刚 肖颖彬 闵家新 张国强 姚珂 周人杰 |
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| 作者单位： | Department of Thoracic Cardiovascular Surgery, Xinqiao Hospital, Third Military Medical University,Chongqing 400037, China |
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| 基金项目： | Supported by Developmental Programming Item of National Keystone Basic Research （G2000016106） and Nature Science Foundation of Chongqing （2005）. |
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| 摘 要： | Objective： To study the 4977-bp deletion of mitochondiral DNA in lung cancer, adjacent normal tissue and health lung and its significance in the development of cancer. Methods： Thirty-seven matched lung cancer/adjacent histologically normal and 20 ＂true＂ normal lung tissue samples from patients without lung cancer were analyzed by long PCR technique. Results： Mitochondrial DNA 4977-bp deletion was detected in 54.1% （20/37） of lung cancers, 59.5% （22/37） of adjacent normal and 30.0% （6/30） of ＂true＂ normal lung tissues. The correlation of 4977-bp deletion with age and smoking factors was present in our data. Conclusion.. Mitochondrial DNA 4977 bp deletion is not specific to lung cancer and unlikely to play an important role in carcinogenesis, and may only reflect the environmental and genetic influences during tumor progression.
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| 关 键 词： | 4977-bp 基因突变 线粒体 肺癌 |
| 收稿时间： | 2005-02-27 |
| 修稿时间： | 2005-06-10 |
Study on 4977-bp deletion mutation of mitochondrial DNA in lung cancer |
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| Dai JiGang;Xiao YingBin;Min GuXin;Zhang GuoJiang;Yao Ke;Zhou RenJie. Study on 4977-bp deletion mutation of mitochondrial DNA in lung cancer[J]. Journal of Medical Colleges of PLA(China), 2005, 20(6): 345-350 |
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| Authors: | Dai JiGang Xiao YingBin Min GuXin Zhang GuoJiang Yao Ke Zhou RenJie |
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| Abstract: | |
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| Keywords: | mitochondrial DNA lung cancer deletion |
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