| 健脾补肾方改善实验动物学习记忆功能的研究 |
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| 引用本文： | 黄光英,陆付耳,杨光,杨明炜,方建国,邹欣,徐丽君,叶望云,李鸣真. 健脾补肾方改善实验动物学习记忆功能的研究[J]. 华中科技大学学报(医学版), 1999, 0(1) |
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| 作者姓名： | 黄光英 陆付耳 杨光 杨明炜 方建国 邹欣 徐丽君 叶望云 李鸣真 |
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| 作者单位： | 同济医科大学附属同济医院中医科，同济医科大学中西医结合研究所 |
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| 基金项目： | 国家中医药管理局资助项目 |
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| 摘 要： | 为观察健脾补肾方对实验动物学习记忆功能的影响，采用避暗法、跳台法和水迷路法研究健脾补肾方对正常幼龄小鼠被动反应、氢溴酸东莨菪碱所致小鼠记忆获得障碍、戊巴比妥钠所致小鼠方向辨别障碍、４００ｍｌ／Ｌ乙醇所致小鼠记忆再现障碍的影响。结果表明：健脾补肾方能减少正常幼龄小鼠５ｍｉｎ内学习试验及记忆测验的错误次数（Ｐ＜０．０５，Ｐ＜０．０１），可提高戊巴比妥钠造成的方向辨别障碍模型小鼠的正确反应平均数和正确反应百分率；亦可延长氢溴酸东莨菪碱和乙醇所致记忆获得与再现障碍模型小鼠的记忆潜伏期，降低５ｍｉｎ内错误次数（Ｐ＜０．０５，Ｐ＜０．０１）。这说明健脾补肾方能增强正常动物的记忆功能，对药物所致动物记忆障碍有改善作用，初步显示健脾补肾方改善学习记忆功能的药理作用
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| 关 键 词： | 健脾补肾方；学习记忆；记忆障碍；方向辨别障碍 |
Effects of Prescription of Bushen Jianpi (BSJP) on the Abilities of Learning and Memory in Mice |
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| Huang Guangying,Lu Fuer,Yang Guang et al Institute of Integrated Traditional Chinese and Western Medicine,Tongji Medical University,Wuhan. Effects of Prescription of Bushen Jianpi (BSJP) on the Abilities of Learning and Memory in Mice[J]. Journal of Huazhong University of Science and Technology(Health Sciences), 1999, 0(1) |
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| Authors: | Huang Guangying Lu Fuer Yang Guang et al Institute of Integrated Traditional Chinese Western Medicine Tongji Medical University Wuhan |
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| Affiliation: | Huang Guangying,Lu Fuer,Yang Guang et al Institute of Integrated Traditional Chinese and Western Medicine,Tongji Medical University,Wuhan 430030 |
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| Abstract: | In order to observe the effects of Bushen Jianpi (BSJP) on the abilities of learning and memory in experimental mice, the tests of avoidance response to darkness, of springing to platform after electric stimulation and of water labrynth, in normal young mice, in the memory obtaining disturbed mice induced by scoplamine hydrobromide and in the orientation disturbed mice induced by pentobarbital sodium as well as in the memory releasing disturbed mice induced by 400 ml/L alcohol, were respectively performed The results showed that BSJP could significantly reduced the error times within 5 min in normal young mice and in dysmnesia groups ( P <0 01, P <0 05), prolonged the incubation periods of memory, greatly improved the average times and percentages of correct response in orientation disturbed mice. It is concluded that BSJP could improve the memory abilities both in normal and in dysmnesia mice induced by some experimental materials It is suggested that BSJP could have the pharmaceutical effects of improving the abilities of learning and memory and thus might be important in the clinical use in the patients with dementia |
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