老年2型糖尿病患者低血糖的相关因素分析

目的探讨住院老年2型糖尿病患者发生低血糖的相关危险因素。方法选择2011年12月～2012年12月河南省商丘市第一人民医院治疗的老年2型糖尿病患者138例。根据是否发生低血糖将其分为未发生低血糖组89例（非低血糖组）及发生低血糖组49例（低血糖组）。对两组患者的临床数据进行统计学比较。结果①低血糖组的体重指数（BMI）为（24.6±4.8）kg/m2,住院天数为（85.6±12.3）d,糖尿病病程为（13.0±8.9）年,而无低血糖组BMI为（26.6±5.7）kg/m2,住院天数为（52.3±10.5）d,病程为（8.7±6.5）年,差异均有统计学意义（P〈0.05）。②低血糖组患者心脑血管疾病相关药物联合使用率较非低血糖组高（P〈0.05）,二甲双胍使用率较非低血糖组低（P〈0.05）,而胰岛素使用率及口服降糖药（OAD）＋胰岛素联用率高于非低血糖组（P〈0.05）。③低血糖组胱抑素C高于非低血糖组（均P〈0.05）,血脂指标中总胆固醇值低于非低血糖组（P〈0.05）,低钾血症的发生率高于非低血糖组（P〈0.05）。结论老年2型糖尿病患者病程长、BMI低、联用胰岛素及OAD,胰岛B细胞功能及肾功能较差均会增加低血糖的发生风险。老年2型糖尿病患者住院期间均予注意,积极预防低血糖的发生。

Analysis of related factors for hypoglycemia in the elderly type 2 diabetes mellitus patients

Objective To research the related risk factors for hypoglycemia in the elderly type 2 diabetes mellitus pa tients.Methods 138 elderly type 2 diabetes mellitus patients from December 2011 to December 2012 in the First People＇s Hospital of Shangqiu City were selected.These patients were divided into the non-hypoglycemia group（n = 89） and hypoglycemia group（n = 49） according to whether with hypoglycemia,and the clinical data between the two groups were compared statically.Results ①The BMI were（24.6±4.8） kg/m2,hospitalization days were（85.6±12.3） days and the course of diabetes mellitus were（13.0±8.9） years in hypoglycemia group,the BMI were（26.6 ±5.7） kg/m2,hospitalization days were（52.3±10.5） days and the course of diabetes mellitus were（8.7 ±6.5） years in non-hypoglycemia group,the differences were statistically significant（P〈0.05）.②The combination rate of related drugs for cardio-cerebrovascular disease in the hypoglycemia group was higher than that in non-hypoglycemia group（P〈0.05）,the usage rate of dimethyl biguanide was lower than that in non-hypoglycemia group（P〈0.05）,and the usage rate of insulin and combination of insulin with oral antidiabetic drug（OAD） was higher than that in non-hypoglycemia group（P〈0.05）.③Cystatin C in hypoglycemia group was higher than that in non-hypoglycemia group（P〈0.05）,total cholesterol in hypoglycemia group was lower than that in non-hypoglycemia group（P〈0.05）,the incidence of hypokalemia in hypoglycemia group was higher than that in non-hypoglycemia group（P〈0.05）.Conclusion The longer disease course,lower BMI,usage of combination of insulin and OAD,worse B cell function and worse kidney function can all increase the risk of hypoglycemia,it is right to pay attention to prevent the hypoglycemia.