| 四种不同品种水蛭生物活性的研究与比较 |
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| 引用本文： | 吴志军,张灵霞,于立华.四种不同品种水蛭生物活性的研究与比较[J].中成药,2006,28(2):232-234. |
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| 作者姓名： | 吴志军 张灵霞 于立华 |
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| 作者单位： | 上海新药研究开发中心,上海,201203 |
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| 基金项目： | 上海市科学技术发展基金(014319318) |
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| 摘 要： | 目的:应用3种酶活性抑制方法测定四种不同品种水蛭的生物活性,为评价水蛭药材质量提供科学依据。方法:分别采用抗凝血酶、抗胰蛋白酶和抗糜蛋白酶3种检测方法,测定了宽体金线蛭、日本医蛭、欧洲医蛭、菲牛蛭样品的生物活性。结果:4种水蛭中,吸血水蛭具有更好的抗凝血酶活性;4种水蛭均具有较好的抗胰蛋白酶和抗糜蛋白酶生物活性。结论:3种酶活性抑制方法可作为水蛭类药材质量控制的依据。
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| 关 键 词： | 水蛭 抗凝血酶 抗胰蛋白酶 抗糜蛋白酶 |
| 文章编号： | 1001-1528（2006）02-0232-03 |
| 收稿时间： | 2005-04-17 |
| 修稿时间： | 2005-04-17 |
Biological activities of four kinds of leeches |
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| WU Zhi-jun,ZHANG Ling-xia,YU Li-hua.Biological activities of four kinds of leeches[J].Chinese Traditional Patent Medicine,2006,28(2):232-234. |
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| Authors: | WU Zhi-jun ZHANG Ling-xia YU Li-hua |
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| Institution: | Shanghai Center of Research and Development of New Drugs, Shanghai 201203, China |
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| Abstract: | AIM: To provide scientific references for leeches by means of the antithrombin,antitrypsin and antichymotrypsin activities of the four kinds of leeches. METHODS: Using antithrombin,antitrypsin and antichymotrypsin activity analysis methods,the four kinds of leeches,they were,Whitmania pigra Whitman,Hirudo nipponia Whitman,Hirudo medicinalis Linnaeus,Hirudinaria manillensis Lesson,were detected. RESULTS: The blood-sucking leeches except whitnania pigra whitman had high antithrombin activity,and these four kinds of leeches were the same antitrypsin and antichymotrypsin activities. CONCLUSION: These three biological activity methods could be considered as reliable indexes in assessing the qualitity of leeches. |
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| Keywords: | leeches antithrombin antitrypsin antichymotrypsin |
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