联合检测hs-CRP、cTnI和心肌酶谱在诊断儿科感染性疾病的应用

目的:探讨超敏C-反应蛋白(hs-CRP)、肌钙蛋白I(cTnI)和心肌酶谱联合检测在儿科感染性疾病鉴别诊断中的意义。方法:应用全自动化学发光免疫分析仪和全自动生化分析仪对3组研究对象血清hs-CRP、cTnI、肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)、乳酸脱氢酶(LDH)和α-羟丁酸脱氢酶(α-HBDH)分别进行测定,并做统计学处理。结果:hs-CRP在细菌感染组中(18.27±3.90)mg/L显著高于病毒组(5.56±0.60)mg/L和健康对照组(4.02±0.60)mg/L(P0.05);cTnI在细菌组中(0.030±0.010)ng/ml显著低于病毒感染组(0.126±0.040)ng/ml(P0.05),但高于健康对照组(0.022±0.010)ng/ml(P0.05);CK、CK-MB、LDH和α-HBDH在细菌感染组中显著低于病毒感染组(P0.05),但高于健康对照组(P0.05)。结论:多项生化标志物联合检测综合判断,可弥补单项检测的不足,有利于感染性疾病患儿鉴别诊断,避免误诊而延误治疗。

Study on combined detection of hs-CRP,cTnI and myocardiac myocardial enzymogram in pediatric infection diseases

Objective.. To investigate the clinical value of combined detection of hs-CRP.eTnI and myocardial enzymogram in pediatric infection diseases. Method：The serum hs-CRP, cTnI, CK, CK-MB, LDH and a-HBDH were detected by automatic ARCHITECT immunoassay analyzer and automatic biochemical analyzer, and were sta- tistically analyzed. Result;The serum hs-CRP levels in bacterial infections and viral infections and normal control group were （18.27 ±3.90）, （5.56 ± 0.60）and （4.02 ±0.60）mg/L, respectively. The serum hs CRP level was higher in bacterial infections than that in viral infections and normal control group. The serum cTnI levels in bacte- rial infections and viral infections and normal control group were （0. 030!0. 010）, （0. 126±0. 040） and （0. 022± 0. 010）ng/ml, respectively. The serum cTnI level was higher in viral infections than that in bacterial infections, but the serum cTnI level was higher in bacterial infections than that in normal control group. The serum myocardi- al enzymogram level was higher in viral infections than that in bacterial infections, but serum myocardial enzymo gram level was higher in bacterial infections than that in normal control group. Conclusion：The combined detection of hs-CRP, cTnI and myocardial enzymogram could compensate the shortages of individual detection, which could avoid misdiagnosis and delayed treatment and play an important role in the differential diagnosis for bacterial and viral infections in children.