蔬菜、水果、鱼类、豆类膳食模式与乳腺癌关系的Meta分析

目的 总结不同人群健康膳食模式特征及其与乳腺癌的关联证据,为我国乳腺癌的预防提供科学依据.方法 中文文献检索1997年1月-2014年6月国内公开发表的相关研究文献,检索数据库包括：中国知网、万方医学网、中文生物医学文献库和维普电子资源,英文文献检索1997年1月-2014年6月公开发表的相关研究,检索数据库包括：Pubmed、Embase、Cochrane database、Medline和Google Scholar.检索词包括膳食模式/饮食（dietary pattern/ food pattern）和乳腺癌/乳腺肿瘤（breast neoplasma/breast cancer/breast carcinoma/mammary cancer）.文献排除标准：（1）重复发表的仅保留样本量大、信息全的一篇.（2）内容为男性乳腺癌的文章.（3）实验性研究、综述、Meta分析、病例-对照研究以及信息不全的文章.用Meta分析对高摄入蔬菜、水果、鱼类和豆制品的膳食模式与乳腺癌关联的效应量进行合并.总结在该类膳食模式上高摄入人群与低摄入人群乳腺癌患病率的合并效应量.合并效应量采用固定效应模型.统计分析采用Stata11.0软件完成.结果 最终纳入英文文献12篇,均为队列研究,未发现符合纳入标准的中文文献.队列研究样本量总数为623 536例,乳腺癌病例为19 707例.结果显示以高摄入蔬菜、水果、鱼类和豆类健康膳食模式对乳腺癌具有保护作用.在这类膳食模式上高摄入人群同低摄入人群相比,队列研究合并乳腺癌发生的风险比（95％可信区间）为0.86（0.80～0.92）.结论 富含蔬菜、水果、鱼类和豆类的健康膳食模式对乳腺癌发病具有保护作用.

Relationship between vegetable,fruit, fish and soybean dietary pattern and breast cancer： a meta-analysis

Objective To understand the relationship between dietary patterns and breast cancer and to provide a possible scientific basis for breast cancer prevention,we performed a meta-analysis in order to evaluate the current relevant literature.Method Meta-analysis was used to pool the effect of vegetable,fruit,fish and soybean dietary patterns on the risk of breast cancer.The breast cancer risk of the highest categories compared to the lowest categories of such dietary patterns was combined using fixed effect model.Searching the database （Chinese databases included CQVIP,WANFANG medicine online,CNKI and SinoMED,and English databases included PubMed,Embase,Cochrane database,Medline and Google Scholar） for articles published between January 1997 and June 2014.All statistical analyses were performed using the Stata 11.0.Result Twelve cohort studies involving 623 536 participants and 19 707 patients with brcast cancer were found to be eligible.Our results indicate that a reasonably healthy dietary pattern （which is characterized by a high consumption of vegetables,fruit,fish and soybean） is beneficial for the prevention of breast cancer.Compared to the lowest categories of such dietary patterns,relative risk （RR） of the highest categories is 0.86 （95% CI 0.80-0.92）.Conclusion A reasonably healthy dietary pattern （which is characterized by a high consumption of vegetables,fruit,fish and soybean） is beneficial for the prevention of breast cancer.