PDCD5蛋白与雄激素受体在人类前列腺癌组织中表达的相关性研究

目的:探讨PDCD5蛋白与雄激素受体(AR)在人类前列腺癌(PCa)组织中表达的相关性。方法:用EnVision法对29例PCa组织切片进行PDCD5及AR免疫组化染色,对其在PCa组织中表达的相关性进行统计学分析。结果:依据定性分析结果对PDCD5在AR(+)及AR(-)两组间PCa组织中的表达进行统计学分析显示两者间比较差异无统计学意义(P>0.05),但PDCD5免疫组化染色定量分析提示PDCD5在PCa AR(+)组中表达明显强于AR(-)组(P<0.01)。结论:PDCD5在PCa AR(-)组中的表达要弱于AR(+)组,提示AR缺失可能导致或伴随PCa细胞凋亡的进一步下调,进而引起AIPC/HRPC的发生。

The relation between expression of PDCD5 and androgen receptor in tissue of human prostate cancer

Objective:To explore the relationship between PDCD5 and AR expressing in prostate cancer(PCa) tissues.Method:The expressions of PDCD5 and AR in 29 PCa samples were tested by EnVision immunohistochemical methods.29 PCa samples were divided into AR(+) and AR(-) group,the expression of PDCD5 was compared between two groups.Result:According to the qualitative analysis,there was no statistical difference in expression of PDCD5 between AR(+) and AR(-) PCa tissues(P>0.05),but the statistical outcome of the quantitative analysis showed the intensity of immunohistochemistry staining of PDCD5 in AR(+) was obviously higher than AR(-) group(P<0.01).Conclusion:The expression of PDCD5 in PCa with AR(-) was obvious lower than that in PCa with AR(+),which suggests deletion of AR may be accompanied with or induce apotosis downregulation and cause AIPC/HRPC.