| 纳米药物晶体的制备技术研究进展 |
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| 引用本文： | 夏怡然,王健,朱金屏,陈芳. 纳米药物晶体的制备技术研究进展[J]. 中国医药工业杂志, 2010, 41(2) |
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| 作者姓名： | 夏怡然 王健 朱金屏 陈芳 |
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| 作者单位： | 上海医药工业研究院,药物制剂国家工程研究中心,上海,201203 |
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| 基金项目： | 国家"重大新药创制"科技重大专项资助 |
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| 摘 要： | 纳米药物晶体可解决多数难溶性药物的溶解度和溶出度问题,近年来成为难溶性药物给药系统研究的热点之一.本文着重综述了纳米药物晶体的制备技术,如沉淀法、分散法、乳化法和微乳化法、超临界流体结晶法等的研究进展.
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| 关 键 词： | 纳米晶体 制备 综述 |
Progress on the Preparation Techniques of Drug Nanocrystals |
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| XIA Yiran,WANG Jian,ZHU Jinpin,CHEN fang. Progress on the Preparation Techniques of Drug Nanocrystals[J]. , 2010, 41(2) |
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| Authors: | XIA Yiran WANG Jian ZHU Jinpin CHEN fang |
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| Abstract: | The solubility and dissolution problems of the majority of the slightly soluble drugs Can be improved by preparing drug nanocrystals.Therefore drug nanocrystals have become one of the focal points of drug delivery systems.Based on recent literatures at home and abroad,this paper emphasizes on the progress of the preparation techniques of drug nanocrystals,such as precipitation method,dispersion method,emulsification and microemulsification, supercritical fluid crystallization,etc. |
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| Keywords: | drug nanocrystals preparation review |
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