抗环瓜氨酸肽抗体等四种抗体在早期类风湿关节炎诊断中的意义

目的 抗环瓜氨酸肽抗体、类风湿因子（RF）三种分型IgG、IgA及ISM在早期类风湿关节炎诊断中的意义及应用价值。方法 90例血清标本，包括32例早期类风湿关节炎，8例强直性脊柱炎，加例未确诊的早期关节炎，30例健康对照，以酶联免疫吸附法（ELISA）检测抗环瓜氨酸肽（CCP）抗体、类风湿因子（RF）-IgG、RF-IgA、RF-IgM，并随诊9个月。结果 RA组抗CCP抗体、RF-IgG、W-IgA、RF-IgM明显高于其余三组（P〈0．05）。抗CCP抗体对RA诊断的特异性、敏感性、阳性预测值及阴性预测值均明显高于RF-IgG、RF-IgA、RF-IgM的相应指标。结论 抗CCP抗体存在于RA疾病的早期，对早期RA有较好的敏感性和特异性，抗CCP抗体检测有利于RA的早期诊断。

Specific antibodies of the early diagnosis of Rheumatoid Arthritis

Objective To assess the diagnosis significance of anti-CCP,RF-IgG,RF-IgA,RF-IgM in patients with early Rheumatoid Arthritis(RA).Methods Anti-CCP,RF-IgG,RF-IgA,RF-IgM were detected by ELISA in sera from 32 patients with early RA,8 patients with Ankylosing Spondylitis(AS),20 patients with early arthritis,30 healthy blood donors.All of them were followed up for 9 months.Results The positive rate of anti-CCP,RF-IgG,RF-IgA and RF-IgM in RA patients were significantly higher than that in other groups(p<0.05).Anti-CCP showed higher sensitivity,specificity,positive predictive value and negative predictive value than that of RF-IgG,RFIgA and RF-IgM.Conclusion Anti-CCP,presents in the early stage of RA,has a perfect value in diagnosis of early RA with better sensitivity and specificity.