1例口腔天疱疮的循证治疗

目的为1例口腔天疱疮患者制定循证治疗方案.方法针对临床问题,计算机检索Cochrane图书馆(2005年第1期)、MEDLINE数据库(1966年～2005年1月)、SUMSEARCH数据库(2005年1月)、TRIPDATABASE数据库(1997年～2005年)、中文生物医学期刊数据库(1994年～2004年),并手工检索<中华皮肤科杂志>等相关的4种中国科技论文统计源期刊(创刊～2004年).结果未检索到系统评价,检索随机对照试验6篇,运用了循证医学方法的高质量综述2篇,以及英国皮肤病医师协会拟订的治疗指南.上述文献显示,皮质类固醇激素是治疗天疱疮的首选药物,但大剂量激素并非较小剂量激素更能有效地控制病情,治疗口腔天疱疮时建议选用中等剂量激素;激素联用免疫抑制剂较单用激素病死率低,联合用药时宜选用环磷酰胺、硫唑嘌呤,应避免选用甲氨喋呤;不应将血浆置换法联合小、中剂量激素作为常规治疗方案;中西医结合治疗可能有效.根据患者病情和检索结果,制定出强的松60mg/d[1mg/(kg·d)]加用硫唑嘌呤100 mg/d的循证治疗方案,经6个月的治疗随访,证实该方案适合患者.结论循证治疗天疱疮患者可有效提高疗效.

Evidence-Based Treatment for a Patient with Oral Pemphigus

Objective To explore the methods of evidence-based individualized treatment for a patient with oral pemphigus. Methods According to clinical problems,we searched The Cochrane Library (Issue 1,2005), MEDLINE (1966Jan.2005), SUMSEARCH (Jan.2005), TRIPDATABASE (19972005), CMCC(19942004) and handsearched four Chinease journals (starting publication2004). Results No Systematic review was found. Six randomised controlled trials, two reviews of high quality and one guideline were identified. We found that corticosteroid was the first-line medicine in the treatment of pemphigus. However, corticosteroid at higher dose did not work more effectively than that at lower dose. Corticosteroid at middle-dose was preferred in treating oral pemphigus. Additionally, corticosteroid combined with immunosuppressants led to lower mortality. Among them, cyclophosphamide and azathioprine were recommended, and methopterin should be avoided. Plasma exchange in combination with corticosteroid at low- or middle-dose should not be recommended in conventional therapy. Chinese traditional treatment combined with Western medicine might work. A treatment with prednisone at the dose of 60 mg/d and in combination with azathioprine 100mg/d was made based on the evaluation of the data available and was proved optimal by 6 months following-up.Conclusions The therapeutic effect of pemphigus has been improved by evidence-based treatment.