蒿甲醚治疗多形性日光疹、慢性光化性皮炎的临床疗效观察

目的观察蒿甲醚胶囊治疗多形性日光疹（polymorphous light eruption，PLE）和慢性光化性皮炎（chronic actinic dermatitis，CAD）的临床疗效及安全性，为光敏性皮肤病寻找更好的治疗方法．方法105例慢性光化性皮炎和63例多形性日光疹病人随机分为治疗组和对照组，治疗组（CAD63例，PLE32例）口服蒿甲醚胶囊，40mg／次，2次／d；对照组口服硫酸羟氯喹片（CAD42例，PLE31例）0．2g／次，2次／d．局部均用10％氧化锌软膏外檫2次／d，其它治疗相同，半月1疗程，治疗两疗程．结果多形性日光疹治疗组总有效率84．4％（27／32）。对照组总有效率80．6％（25／31），两组总有效率经卡方检验统计无显著性差异．慢性光化性皮炎治疗组总有效率85．7％（54／63），对照组81％（34／42），两组总有效率经卡方检验统计无显著性差异．口服蒿甲醚胶囊治疗多形性日光疹和慢性光化性皮炎均未发现副作用．结论蒿甲醚胶囊治疗多形性日光疹和慢性光化性皮炎是有效、安全、方便、经济的．

Clinical Observation of Polymorphous Light Eruption and Chronic Actinic Dermatitis Treated with Artemtherin

Objective To observe the clinical effect and safety of polymorphous light eruption(PLE) and those of chronic actinic dermatitis(CAD) treated with Artemtherin.To further study better treatment methods for photodermatitis.Methods 105 patients with CAD and 63 patients with PLE were divided into the treatment group and the control group randomly.In the treatment group,63 cases of CAD and 32 cases of PLE were treated with Artemtherin.In the control group,42 cases of CAD and 31 cases of PLE treated with Hydroxychlorquine.The dosages of both groups were 40 mg and 200 mg at each time,twice a day respectively.Both groups were topically treated with 10% ointment zinc oxide,twice a day,for one month.Results The effective rate of treatment group and control group with PLE patients were 84.4%(27/32) and 80.6%(25/31),respectively.There was no significant difference between both groups in terms of the effective rate of PLE.The effective rate of treatment group and control group with CAD patients were 85.7%(54/63) and 81%(34/4),respectively.There was not any side-effect reported among these patients treated with Artemtherin.Conclusions It is effective,safe,economic,and convenient to treat PLE and CAD with Artemtherin.