| HPLC法测定人血浆中头孢布烯浓度 |
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| 引用本文： | 徐进,许静,赵真玲. HPLC法测定人血浆中头孢布烯浓度[J]. 儿科药学杂志, 2001, 7(4): 12-13 |
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| 作者姓名： | 徐进 许静 赵真玲 |
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| 作者单位： | 南京医科大学附属南京市儿童医院药剂科, |
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| 摘 要： | 目的:测定血浆中头孢布烯的浓度。方法:采用Hypersil-ODS柱,流动相为乙腈:乙酸铵(pH 4.98,0.05 mol/L)＝2:98(V/V),流速为1. 00 ml/min。结果:标准曲线范围0.3125~20. 00 μg/ml(r=0.9999),回收率试验大于95%,日内和日间变异(RSD%)小于4%。结论:本法专属性好,操作简便,可用于临床血药浓度的监测。
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| 关 键 词： | 头孢布烯 高效液相色谱 血药浓度 |
| 文章编号： | 1009-6884(2001)04-0012-02 |
High-performance Hquid chromatographic assay of ceftibuten in human nlasma |
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| XU Jin,XV Jing,ZHAO Zhenling. High-performance Hquid chromatographic assay of ceftibuten in human nlasma[J]. Journal of Pediatric Pharmacy, 2001, 7(4): 12-13 |
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| Authors: | XU Jin XV Jing ZHAO Zhenling |
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| Abstract: | Objectives: To determine concentration of ceftibuten in plasma. Methods: Ammonium Acetate-acetonitrile(98: 2 v/v) was used as mobile phase with an ultraviolet detector at 254 nm, the flow rate was 1 ml/min. Results: Calibration is linear from 0. 3125 ug/ml to 20. 00 ug/ml(r = 0. 9999). The absolute recovery of ceftibuten was over 95% and the variation with-day and between-day was less than 4%. Conclusion: This assay appears to be suitable for therapeutic drug monitoring. |
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| Keywords: | Ceftibuten HPLC Serum concentration |
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