高迁移率族蛋白B1的致炎细胞因子作用研究进展

目前全身性炎症反应仍然是危重病人死亡的主要原因。近年来发现高迁移率族蛋白B1(HMGB1)这一传统DNA结合蛋白是强大的致炎细胞因子。HMGB1可由单核/巨噬细胞等固有免疫细胞在致炎细胞因子刺激下主动分泌,也可由坏死细胞被动释放。该分子刺激炎症细胞活化并向炎症部位聚集,促进炎症细胞因子分泌造成组织损伤。针对HMGB1的靶向治疗为临床救治感染危重病人拓展了治疗时机,因而具有很大的实际意义。HMGB1的致炎细胞因子作用是炎症损伤的研究热点之一。

Progress in the Research of HMGB1 as a Proinflammatory Cytokine

Systemic inflammatory response syndrome is still the main cause of death in critically ill patients.Recently,the traditional DNA-binding protein HMGB1 was discovered as a potent proinflammatory cytokine.HMGB1 can be both actively secreted by monocytes /macrophages stimulated with proinflammatory cytokines and passively released by necrotic cells.It activates inflammatory cells,making them aggregate in inflammatory sites,promoting the secretion of inflammatory cytokines and leading to tissue injury.Therapies targeting HMGB1 will expand the scope for the clinical treatment of severely infected patients,therefore have great significance.The role of HMGB1 as a proinflammatory cytokine is one of the hot topics in the researches of inflammatory injury.