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| SARS患者急性期外周血CD3+、CD4+及CD8+细胞数量的变化 | |
| 引用本文： | 李建国,陈瑞,魏菁,严海燕,赖琳,徐安平,李依群,江山平,尹松梅,伍卫.SARS患者急性期外周血CD3+、CD4+及CD8+细胞数量的变化[J].免疫学杂志,2004,20(5):382-384. |
| 作者姓名： | 李建国 陈瑞 魏菁 严海燕 赖琳 徐安平 李依群 江山平 尹松梅 伍卫 |
| 作者单位： | 1. 中山大学附属第二医院内科,广东,广州,510120 2. 中山大学附属第二医院医学研究中心,广东,广州510120 3. 中山大学附属第二医院检验科,广东,广州,510120 |
| 基金项目： | 广东省科技厅科研基金资助项目(A002003005) |
| 摘 要： | 目的 探讨SARS患者外周血T淋巴细胞亚群的变化及其临床意义。方法 用全自动血细胞分析仪检测44例SARS患者外周血白细胞计数及分类，用流式细胞仪检测SARS患者外周血T淋巴细胞亚群；并与正常对照组比较。结果 与对照组比较，SARS组患者白细胞总数显著下降，淋巴细胞百分数和绝对数显著下降，粒细胞绝对数显著下降，粒细胞百分数显著增加；CD3^ 、CD4^ 和CD8^ 细胞绝对数显著下降，CD3^ 、CD4^ 及CD8^ 细胞百分数和CD4^ /CD8^ 比值与对照组比较无显著性差异。结论 SARS冠状病毒感染损伤患者细胞免疫功能。 |
| 关 键 词： | SARS 细胞免疫 T淋巴细胞亚群 流式细胞术 |
| 文章编号： | 1000-8861(2004)05-0382-03 |
| 修稿时间： | 2003年9月1日 |
Changes of CD3 +, CD4 +, and CD8 + cells of peripheral blood in acute phase of patients with SARS |
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| LI Jian-guo,CHEN Rui,WEI Jing,YAN Hai-yan,LAI Lin,XU An-ping,LI Yi-qun,JIANG Shan-ping,YIN Song-mei,WU Wei.Changes of CD3 +, CD4 +, and CD8 + cells of peripheral blood in acute phase of patients with SARS[J].Immunological Journal,2004,20(5):382-384. | |
| Authors: | LI Jian-guo CHEN Rui WEI Jing YAN Hai-yan LAI Lin XU An-ping LI Yi-qun JIANG Shan-ping YIN Song-mei WU Wei |
| Institution: | LI Jian-guo1,CHEN Rui1,WEI Jing2,YAN Hai-yan3,LAI Lin1,XU An-ping1,LI Yi-qun1,JIANG Shan-ping1,YIN Song-mei1,WU Wei1 |
| Abstract: | Objective To investigate the changes of T lymphocyte subsets in SARS patients and its significance. Methods Lymphocyte subsets were detected by flow cytometry while the quantity and catalogue of leukocytes were detected with automatic blood cell analyzer in peripheral blood of 44 SARS patients and controls. Results Compared with those of the controls, the quantity of leukocytes and lymphocytes in SARS patients decreased significantly; the proportion of neutrophil increased significantly, but the absolute count of neutrophil decreased significantly; the absolute count of CD3+, CD4+, and CD8+ lymphocytes decreased significantly; and no significant changes found in the proportion of CD3+, CD4+, and CD8+ lymphocyte and ratio of CD4+/CD8+. Conclusion SARS-CoV evidently damages cellular immunity of the patients with SARS. |
| Keywords: | SARS Cellular immunity T lymphocyte subsets Flow cytometry |
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