胃癌组织中E-钙粘附素和血管内皮生长因子的表达

目的：探讨E－钙粘附素（E-cadherin)和血管内皮生长因子（VEGF）表达与胃癌发生、发展的关系，评价E-cadherin和VEGF在胃癌浸润转移及预后判断中的作用。方法：采用SABC免疫组化染色方法，检测20例正常胃粘膜和60例胃癌手术切除标本的E－cadherin和VEGF的表达情况。结果：正常胃粘膜中E－cadherin全部表达，胃癌组织中阳性率为25％，E－cadherin与浸润深度及淋巴结转移相关（P＜0．05）；正常胃粘膜中VEGF均无表达，胃癌组织阳性率为61．7％，VEGF的表达与浸润深度及淋巴结转移显著相关（P＜0．01）；E－cadherin表达和VEGF表达无显著相关性（P＞0．05）。结论：E－cadherin和VEGF表达与胃癌的浸润转移密切相关，检测E－cadherin和VEGD表达有助于胃癌转移及 预后判断。

Expressions of E-cadherin and VEGF in gastric cancer

Aim: To evaluate the expressions of E-cadherin and VEGF in gastric cancer, and evaluate its value for the assessment of tumor metastatic potential and prognosis. Methods: The expressions of E-cadherin protein and VEGF protein were detected in 20 cases of normal gastric mucosa and 60 cases of gastric cancer by SABC immunohistochemistry. Results:E-cadherin expression was observed in all normal gastric mucosa, while the positive rate of E-cadherin in gastric cancer was 25%. E-cadherin expression was associated with invasive depth and lymph node metastasis(P<0.05); VEGF expression was not observed in all normal gastric mucosa, while the positive rate of VEGF in gastric cancer was 61.7%. VEGF expression was associated with invasive depth and lymph node metastasis(P<0.01). The correlation was not observed between E-cadherin expression and VEGF expression. Conclusion: Expressions of E-cadherin and VEGF are associated with invasion and metastasis in gastric cancer. Determination of E-cadherin and VEGF is helpful in predicting tumor metastatic potential and prognosis for patients with gastric cancer.