Response to total sleep deprivation and clomipramine in endogenous depression |
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| Authors: | S Elsenga R H Van den Hoofdakker |
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| Affiliation: | 1. University of Carthage, Faculty of Sciences of Bizerte, Laboratory of Integrative Physiology, Jarzouna, 7021, Tunisia;2. University of Tunis El Manar, Higher Institute of Applied Biological Sciences of Tunis, 9, Rue Zouhair Essafi, 1006, Tunis, Tunisia;3. University of Carthage, Faculty of Sciences of Bizerte, Environment Biomonitoring Laboratory, Jarzouna, 7021, Tunisia;1. Department of Pharmacology, Graduate School of Biomedical & Health Sciences, Hiroshima University, Kasumi 1-2-3, Minami-ku, Hiroshima, Japan;2. Division of Psychiatry and Neuroscience, Institute for Clinical Research, National Hospital Organization (NHO) Kure Medical Center and Chugoku Cancer Center, 3-1 Aoyama, Kure, Japan;3. Department of Psychiatry, National Hospital Organization (NHO) Kure Medical Center and Chugoku Cancer Center, 3-1 Aoyama, Kure, Japan |
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| Abstract: | In 44 endogenously depressed patients, response to total sleep deprivation (TSD) was investigated as a function of several biographical and clinical variables. All patients were subjected to a schedule of sleep-TSD-sleep-TSD. Antidepressant drug treatment (clomipramine) was started on the day before the first TSD. Sex, age, educational status, number of previous hospitalizations and duration of the current depressive episode were not related to the response to either the first or the second TSD. Likewise, no significant differences were found in the responses of unipolar and bipolar patients. In contrast, diurnal variation appeared to be positively correlated with response to TSD. Depressives with psychotic features reacted more favourably than non-psychotic depressives. |
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