LIGHT-related molecular network in the regulation of innate and adaptive immunity |
| |
| Authors: | Yanhui Xu Koji Tamada Lieping Chen |
| |
| Affiliation: | (1) Molecular Biology Graduate Program, Mayo Clinic College of Medicine, Rochester, MN;(2) Present address: The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, 1550 Orleans Street, 21205 Baltimore, MD |
| |
| Abstract: | The LIGHT-related molecular network is composed of at least seven interacting receptors and ligands. Recent studies reveal that this network has profound immune regulatory functions for both innate and adaptive immunity. Experimental data support the concept that this network may also play roles in the pathogenesis of human diseases including cancer, infection, transplantation tolerance, and autoimmune diseases. In this review, we attempt to dissect each molecular interaction in detail and assemble them in the context of their roles in the pathogenesis and possible therapeutic potential in human diseases. |
| |
| Keywords: | LIGHT HVEM LTβ R BTLA T cell activation T cell-mediated diseases |
| 本文献已被 PubMed SpringerLink 等数据库收录！ |
|
