| 中枢性降压药莫索尼定的合成工艺 |
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| 引用本文： | 武引文,梅和珊,张忠敏,吕新英,颜廷仁. 中枢性降压药莫索尼定的合成工艺[J]. 中国药物化学杂志, 2001, 11(1): 45-46 |
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| 作者姓名： | 武引文 梅和珊 张忠敏 吕新英 颜廷仁 |
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| 作者单位： | 1. 河北医科大学药学院,河北 石家庄 050017
2. 河北省灵寿县中学，河北 灵寿 050500 |
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| 摘 要： | 以乙脒盐酸盐为原料，经环合硝化、氯化、还原、加成脱水、醇解成盐合成了中枢性降压药莫索尼定，总产率为24.8%。在氯化反应中，以三氯氧磷为氯化剂，产率为92.8%。在还原反应中，以铁粉为还原剂，完成反应后进行水蒸气蒸馏，产率为87.7%。
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| 关 键 词： | 莫索尼定；合成；硝化；还原 |
| 文章编号： | 1005-0108(2001)01-0045-02 |
| 修稿时间： | 2000-08-28 |
Synthesis of the SecondaryGeneration of Central Hypotensor Moxonidine |
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| WU Yin wen ,MEI He shan ,ZHANG Zhong min ,LU XIN ying ,YAN Ting ren. Synthesis of the SecondaryGeneration of Central Hypotensor Moxonidine[J]. Chinese Journal of Medicinal Chemistry, 2001, 11(1): 45-46 |
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| Authors: | WU Yin wen MEI He shan ZHANG Zhong min LU XIN ying YAN Ting ren |
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| Affiliation: | WU Yin wen 1,MEI He shan 1,ZHANG Zhong min 1,LU XIN ying 2,YAN Ting ren 1 |
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| Abstract: | Moxonidine is known as the central hypotensor of the secondary generation.It was synthesized from acetamidine hydrochloride as the starting material via cyclization,nitration,chlorination,reduction,addition and dehydration,alcoholysis and salt formation.The overal yield was 24 8%.The yield of chlorination was 92 8%,using phosphorus oxychloride as the chlorinating agent.The yield of reduction was 87 7%,using iron powder as the reducting agent and steam distillation as the separation method. |
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| Keywords: | moxonidine synthesis nitration reduction |
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