血浆同型半胱氨酸与颅内动脉瘤的关系

目的 探讨血浆同型半胱氨酸(Hcy)、血清叶酸、维生素B12水平与颅内动脉瘤的关系.方法 采用化学发光法检测80例颅内动脉瘤患者和60例对照者血浆Hcy、血清叶酸、维生素B12水平,相关危险因索用logistic回归分析.结果 颅内动脉瘤组平均血浆Hcy水平明显高于对照组(P=0.005),两组中血浆Hcy升高分别有38例(48%)和9例(15%)(X2=16.239,P＜0.001);颅内动脉瘤组平均血清叶酸、维生素B12水平明显低于对照组(P=0.01;P=0.005);颅内动脉瘤患者血浆Hcy水平与血清叶酸、维生素B12水平呈负相关(P＜0.05).多因素logistic回归分析显示:血浆Hcy是颅内动脉瘤发病的独立危险因素,比值比(OR)=3.961P=0.019,95%可信区间(CI):1.255～12.500].结论 高Hcy血症与颅内动脉瘤发病有密切关系,可能是颅内动脉瘤发病的一个独立危险因素;血浆Hcy水平升高可能与血清叶酸、维生素B12水平降低有关.

Relationship between plasma homocysteine level and intracranial aneurysm

Objective To study the relationship between plasma homocysteine,folate and VitB12 levels and intracranial aneurysn.Methods The levels of plasma homocysteine,folate and VitB12 of 80 intracranial aneurism patients and 60 healthy sabiects were measured by chemilumi-nescnet immunoassay.Results The mean level of plasma homocysteine in intracranial aneurysm patients Was significantly higher than that in healthy controls(P=0.005),but the level of folate and VitB12 was respectively lower than that in controls(P=0.01,P=0,005).The plasma Hcy levels were increased in 47.5%(38/80)of the patients and 15%(9/60)of the controls(X2=16.239,P＜0.001)The level of plasma homocysteine was negatively correhted with the levels of folate and VitB12(P＜0.05)Logistic procedure analysis showed that hyperhomocysteinemia Was an independent risk factor for intraeranial aneurysm(P=0.019).The odds ratio of hyperhomocyst-einemia was 3.961(95%CI:1.255～12.500).Conclusion Hyperhomocysteinemia is intimatly associated with intracranial aneurysm.and it may be a new independent risk factor for intracranial aneurysm.Hyperhomocysteinemia may be associated with the decrease of folate and VitB12 levels.