头孢吡肟和头孢他啶治疗重症下呼吸道感染疗效比较

目的 比较头孢吡肟和头孢他啶治疗重症下呼吸道感染的疗效和安全性。方法 选取住院治疗的重症下呼吸道感染患者62例进行随机比较，头孢吡肟组28例4g/d，头孢他啶组３４例4g/d，疗程７－１０天，静脉注射。结果 两组临床疗效差异有显著性（Ｐ＜0.05)，分别为89.3%及70.6%。细菌清除率分别为８５％及67.9％。人体外药敏试验上看，细菌对头孢吡肟敏感率优于头孢他啶，尤其是革兰氏阳性球菌。两组患者无皮疹及其它副作用。结论 在治疗重症下呼吸道感染患者中，头孢吡较头孢他啶更加安全有效，而且对于革兰氏阳性球菌感染者疗效明显优于头孢他啶，可作为首选经验性用药。

Comparative study of the efficacy of Cefepime and Ceftazidime in treating serious lower respiratory tract infections

Objective To compare the efficacy and safety of Cefepime and Ceftazidime in treating serious lower respiratory tract infections.Methods 62 patients with serious lower respiratory tract infections were selected to make randomized comparative study.28 patients in group Cefepime received 4g of Cefepime intravenously once a day,34 patients in group Ceftazidime received 4g of Ceftazidime intravenously once a day,the course of treatment was 7 to 10 days.Results The efficacy of Cefepime and Ceftazidime were 89.3% and 70.6% respectively,the difference between two groups was obvious( P <0.05).The bacterial eradication rate of two groups were 85% and 67.9%.By determining drug susceptibility we can see that bacter's sensitivity to Cefepime was higher than that to Ceftazidime,especially GPC.No adverse events occurred.Conclusion The study indicate that for the patients with serious lower respiratory tract infections,Cefepime is more safe and effective than Ceftazidime for the patients with GPC infections,Cefepime can be served as experimental drug.