非粘附性液体栓塞材料Onyx栓塞治疗脑动静脉畸形30例

目的对比分析新型非粘附性液体栓塞材料ONYX与NBCA对脑动静脉畸形（AVM）的栓塞率，有效性和安全性。方法选取2006年1月至2009年9月60例脑AVM患者，按队列随机原则随机分为ONYX组（30例）和NBCA组（30例），分不给予ONYX和NBCA栓塞治疗。对比分析2组不同AVM直径（〈3cm，3—6cm和〉6cm）及不同区域AVM的栓塞率、并发症和症状、体征变化情况。结果Onyx对直径3～6cm，〉6cm和大脑功能区AVM的栓塞率优于NBCA（P〈0．05），而对直径〈3cm，大脑深部和小脑半球AVM的栓塞率未显示优于NBCA（P〉0．05），安全性也有所提高。结论ONYX在畸形血管内的弥散程度更完全，效果更可靠，栓塞的安全性和病灶闭塞率都有明显的提高，值得临床推广。

The study of Intracranial arteriovenous malformation em-bolization with nonadhesiveness material ONYX in 30 cases

Objective To study the different efficacy and safe of Intracranial arteriovenous malformation em-bolization with nonadhesiveness material ONYX and NBCA.Methods 60 cases with cerebral arteriovenous malformation are randomized into ONYX group(30 cases)and NBCA group(30 cases),which accept the em-bolization with ONYX and NBCA respectively.To study the different clinical embolism rate,ocomplication,efficacy and safe.according to different AVM diameter and area in the the tow groups.Results The patients who have cerebral arteriovenous malformation with diameter>6 cmor3～6 cm and in cerebral function area in ONYX group have the better embolism rate than that in the NBCA group(P<0.05);but not in patients who have cerebral AVM with diameter<3 cm and in cerebral deep area or cerebellar hemisphere(P>0.05).Condusion ONYX has the better efficacy and safe in cerebral AVM em-bolization,which is deserved to spread.