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| 乌桕叶化学成分研究 | |
| 引用本文： | 高莉,田华,吕培军,王佳平,王易芬. 乌桕叶化学成分研究[J]. 中国中药杂志, 2015, 40(8): 1518-1522 |
| 作者姓名： | 高莉 田华 吕培军 王佳平 王易芬 |
| 作者单位： | 1. 中国科学院大学昆明植物研究所植物化学与西部资源持续利用国家重点实验室,云南昆明650201;中国科学院大学,北京100049 2. 河南大学,河南开封,475000 3. 中国科学院大学,北京,100049 4. 中国科学院大学昆明植物研究所植物化学与西部资源持续利用国家重点实验室,云南昆明,650201 |
| 基金项目： | 云南省中青年学术和技术带头人后备人才培养计划项目(2007PY01-49) |
| 摘 要： | 通过利用正相硅胶色谱、大孔吸附树脂柱色谱、葡聚糖凝胶LH-20色谱、制备薄层色谱和半制备HPLC等多种分离方法,运用现代波谱技术对所分离的化合物进行结构鉴定,从乌桕Sapium sebiferum叶中分离得到15个化合物,分别鉴定为(+)-(7R,7′R,7"S,7(')S,8S,8′S,8"S,8(')S)-4",4(')-dihydroxy-3,3′,3",3('),5,5′-hexamethoxy-7,9';7',9-diepoxy-4,8";4′,8(')-bisoxy-8,8′-dineo-lignan-7",7('),9",9(')-tetraol(1),1-(4′-hydroxy-3'-methoxyphenyl)-2-[4"-(3-hydroxy propyl)-2",6"-dimethoxyphenoxy]propane-1,3-dio1(2),苏式-2,3-二-(4-羟基-3-甲氧基苯)-3-甲氧基丙醇(3),threo-5-hydroxy-3,7-dimethoxyphenylpropane-8,9-diol(4),boropinol B(5),threo-8S-7-methoxysyringylglycerol(6),5-羟甲基糠醛(7),5-甲氧甲基-1H-吡咯-2-甲醛(8),槲皮素(9),山柰酚(10),没食子酸乙酯(11),松柏醛(12),香草醛(13),7-羟基-6-甲氧基香豆素(14),正二十七烷醇(15),除化合物9～ 11,14外,以上化合物均为首次从乌桕中分离得到. |
| 关 键 词： | 乌桕 乌桕属 酚类 |
| 收稿时间： | 2014-11-17 |
Chemical constituents of Sapium sebiferum leaves |
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| GAO Li,TIAN Hu,LV Pei-jun,WANG Jia-ping and WANG Yi-fen. Chemical constituents of Sapium sebiferum leaves[J]. China Journal of Chinese Materia Medica, 2015, 40(8): 1518-1522 | |
| Authors: | GAO Li TIAN Hu LV Pei-jun WANG Jia-ping WANG Yi-fen |
| Affiliation: | State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, University of Chinese Academy of Sciences, Kunming 650201, China;University of Chinese Academy of Sciences, Beijing 100049, China,State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, University of Chinese Academy of Sciences, Kunming 650201, China;University of Chinese Academy of Sciences, Beijing 100049, China,He'nan University, Kaifeng 475000, China,University of Chinese Academy of Sciences, Beijing 100049, China and State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, University of Chinese Academy of Sciences, Kunming 650201, China |
| Abstract: | Chemical constituents of ethyl acetate extract of Sapium sebiferum leaves were isolated and purified by various chromatographic methods, including column chromatographies over silica gel, macroporous adsorption resin, and Sephadex LH-20, as well as preparative TLC and semi preparative HPLC. As a results, 15 compounds were separated from Sapium sebiferum leaves and their structures were examined by spectral analysis including NMR and MS data and identified as(+)-(7R,7'R,7"S,7"'S,8S,8'S,8"S,8"'S)-4",4"'-dihydroxy-3,3',3",3"',5,5'-hexamethoxy-7,9';7',9-diepoxy-4,8";4',8"'-bisoxy-8,8'-dineo-lignan-7",7"',9",9"'-tetraol(1),1-(4'-hydroxy-3'-methoxyphenyl)-2-[4"-(3-hydroxypropyl)-2",6"-dimethoxyphenoxy]propane-1,3-diol(2),Thero-2,3-bis-(4-hydroxy-3-methoxypheyl)-3-methoxy-propanol(3),threo-5-hydroxy-3,7-dimethoxyphenyl propane-8,9-diol(4),boropinol B(5),threo-8S-7-methoxysyringylglycerol(6),5-hydroxymethylfurfural(7),5-(methoxy-methyl)-1H-pyrrole-2-carbaldehyde(8),quercetin(9),kaempferol(10), ethyl gallate(11), coniferaldehyde(12), vanillin(13), 7-hydroxy-6-methoxy-2H-1-benzopyran-2-one(14),and 1-heptacosanol(15). All compounds except for compounds 9-11,14 were separated from this plant for the first time. |
| Keywords: | Sapium sebiferum Sapium phenolics |