| pH对热毒宁栓中绿原酸、栀子苷体外直肠渗透性的影响 |
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| 引用本文： | 闫明,韦迎春,孟瑾,徐殿红,吴云,萧伟.pH对热毒宁栓中绿原酸、栀子苷体外直肠渗透性的影响[J].中国中药杂志,2015,40(8):1493-1496. |
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| 作者姓名： | 闫明 韦迎春 孟瑾 徐殿红 吴云 萧伟 |
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| 作者单位： | 1. 江苏康缘药业股份有限公司,江苏连云港222001;中药制药过程新技术国家重点实验室,江苏连云港222001
2. 江苏康缘药业股份有限公司,江苏连云港,222001 |
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| 摘 要： | 目的:考察不同pH的热毒宁栓中绿原酸、栀子苷的直肠渗透特性.方法:制备4种不同pH的热毒宁栓,将其置于底部扎口的大鼠直肠中,以生理盐水作为接收液,进行直肠体外渗透性研究,并采用HPLC对接收液中的绿原酸、栀子苷含量进行测定,绘制给药24 h的累积渗透曲线,渗透速率以及Q-t方程.结果:绿原酸的渗透量随着pH的增高呈下降趋势,栀子苷的渗透量平稳.结论:热毒宁栓的pH影响主要药效成分的直肠渗透吸收,在进行栓剂成型工艺研究时需要对产品的最优pH范围进行深入研究.
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| 关 键 词： | 栓剂 绿原酸 栀子苷 直肠渗透性 pH |
| 收稿时间： | 2014/9/12 0:00:00 |
Study on effect of pH on rectum permeability of active ingredients in Reduning suppositories in vitro |
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| YAN Ming,WEI Ying-chun,MENG Jin,XU Dian-hong,WU Yun and XIAO Wei.Study on effect of pH on rectum permeability of active ingredients in Reduning suppositories in vitro[J].China Journal of Chinese Materia Medica,2015,40(8):1493-1496. |
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| Authors: | YAN Ming WEI Ying-chun MENG Jin XU Dian-hong WU Yun and XIAO Wei |
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| Institution: | Jangsu Kanion Pharmaceutical Co., Ltd., Lianyungang 222001, China;State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang 222001, China,Jangsu Kanion Pharmaceutical Co., Ltd., Lianyungang 222001, China;State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang 222001, China,Jangsu Kanion Pharmaceutical Co., Ltd., Lianyungang 222001, China;State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang 222001, China,Jangsu Kanion Pharmaceutical Co., Ltd., Lianyungang 222001, China,Jangsu Kanion Pharmaceutical Co., Ltd., Lianyungang 222001, China;State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang 222001, China and Jangsu Kanion Pharmaceutical Co., Ltd., Lianyungang 222001, China;State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang 222001, China |
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| Abstract: | Objective:To investigate the effect of different pH on rectum permeability of chlorogenic acid and geniposide.Method:Four kinds of Reduning suppositories of different pH were separated and put into the rectum to study the suppositories in vitro and the content of chlorogenic acid and geniposidesamples was determined by HPLC to calculate the permeation in 24 hours.Result:With increase of pH within 2.5-7.4, the steady state flux of chlorogenic acid was increased, but the steady state flux of geniposidesamples was steady.Conclusion:Adjusted the pH can increase the rectum permeability of active ingredients in Reduning auppositories. |
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| Keywords: | suppositories chlorogenic acid geniposidesamples phosphate buffer rectum permeability pH |
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