The evolution and mechanisms of nucleotide excision repair proteins |
| |
Authors: | Christophe Rouillon Malcolm F White |
| |
Institution: | Centre for Biomolecular Sciences, University of St Andrews, North Haugh, St Andrews, Fife KY16 9ST, UK |
| |
Abstract: | Nucleotide excision repair (NER) pathways remove a wide variety of bulky and helix-distorting lesions from DNA, and involve the coordinated action of damage detection, helicase and nuclease proteins. Most archaeal genomes encode eucaryal-type NER proteins, including the helicases XPB and XPD and nuclease XPF. These have been a valuable resource, yielding important mechanistic and structural insights relevant to human health. However, the nature of archaeal NER remains very uncertain. Here we review recent studies of archaeal NER proteins relevant to both eucaryal and archaeal NER systems and the evolution of repair pathways. |
| |
Keywords: | Archaea XPB XPD XPF Helicase Nuclease |
本文献已被 ScienceDirect 等数据库收录! |
|