Left ventricular diastolic dyssynchrony assessed with phase analysis of gated myocardial perfusion SPECT: a comparison with tissue Doppler imaging

Purpose

The aim of the current study was to evaluate the feasibility of phase analysis on gated myocardial perfusion SPECT (GMPS) for the assessment of left ventricular (LV) diastolic dyssynchrony in a head-to-head comparison with tissue Doppler imaging (TDI).

Methods

The population consisted of patients with end-stage heart failure of New York Heart Association functional class III or IV with a reduced LV ejection fraction of ??35%. LV diastolic dyssynchrony was calculated using TDI as the maximal time delay between early peak diastolic velocities of two opposing left ventricle walls (diastolic mechanical delay). Significant LV diastolic dyssynchrony was defined as a diastolic mechanical delay of >55?ms on TDI. Furthermore, phase analysis on GMPS was performed to evaluate LV diastolic dyssynchrony; diastolic phase standard deviation (SD) and histogram bandwidth (HBW) were used as markers of LV diastolic dyssynchrony.

Results

A total of 150 patients (114 men, mean age 66.0?±?10.4?years) with end-stage heart failure were enrolled. Both diastolic phase SD (r?=?0.81, p?r?=?0.75, p?55?ms) showed significantly larger diastolic phase SD (68.1?±?13.4° vs. 40.7?±?14.0°, p?p?Conclusion Phase analysis on GMPS showed good correlations with TDI for the assessment of LV diastolic dyssynchrony.