慢性乙型肝炎患者血清IL-6水平与多聚人血清白蛋白受体的相关性研究

目的　探讨慢性乙型肝炎患者血清白细胞介素 6 (Interleukin 6 ,IL 6 )与乙型肝炎病毒(HBV)复制的关系及其在肝脏病理损伤中的作用。方法　对 6 6例不同类型的乙型肝炎标志物阳性患者及不同程度的慢性乙型肝炎患者血清IL 6水平进行检测 ,同时检测HBV复制标志物———多聚人血清白蛋白受体 (polymerizedhumanserumalbuminreceptor,PHSA R)。结果　HBV携带组及轻度慢性乙型肝炎组中PHSA R阳性患者血清IL 6水平高于PHSA R阴性患者 (P <0 .0 1) ;38份PHSA R阳性患者PHSA R检测吸光度A值与血清IL 6水平显著相关 ,r =0 .6 94(P <0 .0 1) ;血清IL 6水平按乙型肝炎病情严重程度依次增高。结论　血清IL 6水平与HBV复制及肝脏损伤程度相关 ,血清IL 6水平检测作为指示乙型肝炎患者HBV的复制及辅助病情和疗效的判定 ,可能是一个新的有价值的指标

Correlation between IL-6 levels and polymerized human serum albumin ceptor (PHSA-R) in serum of chronic hepatitis patients

Objective To investigate the relationship between interleukin-6(IL-6) levels in serum and HBV replication and the role of IL-6 in liver damage in chronic hepatitis B patients.Methods Detected IL-6 levels and polymerized human serum albumin receptor (PHSA-R) in serum of different type of HBV markes positive patients and of different degree of chronic hepatitis B patients.Results The results showed that the serum IL-6 levels were increased singnificantly in PHSA-R positive patients than in PHSA-R negative patients in chronic hepatitis B (P<0.01).The serum IL-6 levels were correlated with the levels of PHSA-R (r=0.694,P<0.01),and the degree of symptoms.Conclusion This study suggested that the IL-6 levels in serum of hepatitis B patients correlated HBV replication and the degree of liver demage,serum IL-6 levels may be used as a value indicating of HBV replication,the degree of symptoms and the effect of treatment.