Elevated transglutaminase‐2 expression in the epidermis of psoriatic skin and its role in the skin lesion development |
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| Authors: | Ching‐Chyuan Su Tzu‐Rong Su Ji‐Ching Lai Gregory‐J Tsay Hung‐Ke Lin |
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| Institution: | 1. Antai Medical Care Cooperation Antai Tian‐Sheng Memorial Hospital (TSMH), Pingtung, Taiwan;2. Department of Beauty Science, Meiho University, Pingtung, Taiwan;3. Research Assistant Center, Changhua Show Chwan Memorial Hospital, Changhua, Taiwan;4. Division of Immunology and Rheumatology, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan;5. School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan;6. Institute of Microbiology and Immunology, Chung Shan Medical University, Taichung, Taiwan;7. Division of Immunology and Rheumatology, Department of Internal Medicine, Show Chwan Memorial Hospital, Changhua, Taiwan |
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| Abstract: | Psoriasis, an inflammatory skin disease triggered by the immune system, presents keratinocyte hyperproliferation, differentiation and angiogenesis. The role of transglutaminase‐2 (TG2) in psoriasis has not been fully established yet. In this retrospective, non‐randomized and non‐blinded study, skin biopsies were collected from 37 psoriatic patients and immunohistochemical staining was performed. TG2 staining was positive in all 37 samples, among which 32 were strong and five weak. The localization of TG2 staining was present in the epidermis and spreading from basal layer to stratum granulosum in decreasing staining intensity. However, TG2 was also expressed in the basal layer in the non‐lesional site of psoriasis and the skin of healthy people. The presence of TG2 was not associated with disease duration, stage of disease and subtype of psoriasis. Overexpression of TG2 seems to be an important role in psoriatic development. |
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| Keywords: | immune system immunohistochemical staining psoriasis skin transglutaminase‐2 |
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